Open AccessJournal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
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TLDR
Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.About:
This article is published in Japanese Circulation Journal-english Edition.The article was published on 1998-02-28 and is currently open access. It has received 9749 citations till now. The article focuses on the topics: Disease.read more
Citations
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Assessment of endothelial damage in atherosclerotic vascular disease by quantification of circulating endothelial cells. Relationship with von Willebrand factor and tissue factor.
TL;DR: Evidence of direct endothelial cell injury is demonstrated in patients with IRP that correlated with vWf and TF, but that this is less severe than in AMI.
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Air pollution: the "Heart" of the problem.
TL;DR: Air pollution exposure is associated with an increased risk of acute and chronic cardiovascular mortality and the subsequent generation of a systemic inflammatory response could link air pollution exposure with the development of cardiovascular disease.
Journal ArticleDOI
Extracellular calcium elicits a chemokinetic response from monocytes in vitro and in vivo
Ivona T. Olszak,Mark C. Poznansky,Richard H. Evans,Douglas P. Olson,Claudine H. Kos,Martin R. Pollak,Edward M. Brown,David T. Scadden +7 more
TL;DR: Extracellular calcium functions as an ionic chemokinetic agent capable of modulating the innate immune response in vivo and in vitro by direct and indirect actions on monocytic cells.
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Multimodal clinical imaging to longitudinally assess a nanomedical anti-inflammatory treatment in experimental atherosclerosis.
Mark E. Lobatto,Zahi A. Fayad,S. Silvera,Esad Vucic,Claudia Calcagno,Venkatesh Mani,Stephen D. Dickson,Klaas Nicolay,Manuela Banciu,Raymond M. Schiffelers,Josbert M. Metselaar,Louis van Bloois,Hai Shan Wu,John T. Fallon,James H.F. Rudd,Valentin Fuster,Edward A. Fisher,Gert Storm,Willem J. M. Mulder +18 more
TL;DR: This study evaluates a powerful two-pronged strategy for efficient treatment of atherosclerosis that includes nanomedical therapy of Atherosclerotic plaques and the application of noninvasive and clinically approved imaging techniques to monitor delivery and therapeutic responses.
References
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Journal ArticleDOI
The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
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Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
J. Shepherd,Stuart M. Cobbe,Ian Ford,C. G. Isles,AR Lorimer,Peter W. Macfarlane,J. H. Mckillop,Christopher J. Packard +7 more
TL;DR: Treatment with pravastatin significantly reduced the incidence of myocardial infarction and death from cardiovascular causes without adversely affecting the risk of death from noncardiovascular causes in men with moderate hypercholesterolemia and no history of my Cardiac Infarction.
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Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
TL;DR: The reduction associated with the use of aspirin in the risk of a first myocardial infarction appears to be directly related to the level of C-reactive protein, raising the possibility that antiinflammatory agents may have clinical benefits in preventing cardiovascular disease.
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The Pathogenesis of Atherosclerosis — An Update
TL;DR: A response-to-injury hypothesis of atherogenesis proposes that "injury" to the endothelium is the initiating event in atherosclerosis, and intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of Atherosclerosis.
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Compensatory Enlargement of Human Atherosclerotic Coronary Arteries
Seymour Glagov,Elliot Weisenberg,Christopher K. Zarins,Regina Stankunavicius,George J. Kolettis +4 more
TL;DR: It is concluded that human coronary arteries enlarge in relation to plaque area and that functionally important lumen stenosis may be delayed until the lesion occupies 40 percent of the internal elastic lamina area.