Open AccessJournal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
Reads0
Chats0
TLDR
Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.About:
This article is published in Japanese Circulation Journal-english Edition.The article was published on 1998-02-28 and is currently open access. It has received 9749 citations till now. The article focuses on the topics: Disease.read more
Citations
More filters
Journal ArticleDOI
Casein hydrolysate containing the antihypertensive tripeptides Val-Pro-Pro and Ile-Pro-Pro improves vascular endothelial function independent of blood pressure-lowering effects: contribution of the inhibitory action of angiotensin-converting enzyme.
Tatsuhiko Hirota,Kohji Ohki,Rikako Kawagishi,Yoshitaka Kajimoto,Seiichi Mizuno,Yasunori Nakamura,Masafumi Kitakaze +6 more
TL;DR: It is concluded that casein hydrolysate containing VPP and IPP improves the vascular endothelial dysfunction in subjects with mild hypertension and could help to prevent cardiovascular diseases in hypertensive subjects.
Journal ArticleDOI
Reduced expression of endothelial cell markers after 1 year treatment with simvastatin and atorvastatin in patients with coronary heart disease
TL;DR: The reduction in proinflammatory and to some extent haemostatic markers of endothelial function after 1 year treatment with either simVastatin or atorvastatin may be indicative of a less activated state of the endothelium which possibly may contribute to modulation of the progression of atherosclerosis.
Journal ArticleDOI
Endothelial nitric oxide synthase transgenic models of endothelial dysfunction.
Dmitriy N. Atochin,Paul L. Huang +1 more
TL;DR: Together, eNOS knockout mice and ENOS S1177 mutant mice are useful tools to study the effects of total genetic deficiency of eN OS as well as varying degrees of endothelial dysfunction caused by eNos S 1177 phosphorylation.
Journal ArticleDOI
Three-dimensional numerical simulation of receptor-mediated leukocyte adhesion to surfaces: Effects of cell deformability and viscoelasticity
TL;DR: Numerical simulations demonstrate the formation and breakup of membrane tethers observed in vitro and suggest that the elasticity of the cytoplasm is responsible for a teardrop shape of rolling leukocytes in vivo.
Journal ArticleDOI
Aged garlic extract improves endothelial function in men with coronary artery disease
Michael J.A. Williams,Wayne H.F. Sutherland,Maree P. McCormick,David J. Yeoman,Sylvia A. de Jong +4 more
TL;DR: It is suggested that short‐term treatment with AGE may improve impaired endothelial function in men with CAD treated with aspirin and a statin and whether improvement in endothelium function decreases the risk of future cardiovascular events remains to be determined.
References
More filters
Journal ArticleDOI
The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
Journal ArticleDOI
Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
J. Shepherd,Stuart M. Cobbe,Ian Ford,C. G. Isles,AR Lorimer,Peter W. Macfarlane,J. H. Mckillop,Christopher J. Packard +7 more
TL;DR: Treatment with pravastatin significantly reduced the incidence of myocardial infarction and death from cardiovascular causes without adversely affecting the risk of death from noncardiovascular causes in men with moderate hypercholesterolemia and no history of my Cardiac Infarction.
Journal ArticleDOI
Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
TL;DR: The reduction associated with the use of aspirin in the risk of a first myocardial infarction appears to be directly related to the level of C-reactive protein, raising the possibility that antiinflammatory agents may have clinical benefits in preventing cardiovascular disease.
Journal ArticleDOI
The Pathogenesis of Atherosclerosis — An Update
TL;DR: A response-to-injury hypothesis of atherogenesis proposes that "injury" to the endothelium is the initiating event in atherosclerosis, and intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of Atherosclerosis.
Journal ArticleDOI
Compensatory Enlargement of Human Atherosclerotic Coronary Arteries
Seymour Glagov,Elliot Weisenberg,Christopher K. Zarins,Regina Stankunavicius,George J. Kolettis +4 more
TL;DR: It is concluded that human coronary arteries enlarge in relation to plaque area and that functionally important lumen stenosis may be delayed until the lesion occupies 40 percent of the internal elastic lamina area.