Open AccessJournal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
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TLDR
Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.About:
This article is published in Japanese Circulation Journal-english Edition.The article was published on 1998-02-28 and is currently open access. It has received 9749 citations till now. The article focuses on the topics: Disease.read more
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Hypolipidemic and antioxidant effects of dandelion (Taraxacum officinale) root and leaf on cholesterol-fed rabbits.
Ung-Kyu Choi,Ok-Hwan Lee,Joo Hyuk Yim,Chang-Won Cho,Young Kyung Rhee,Seong-Il Lim,Youngchan Kim +6 more
TL;DR: Results show that treatment with dandelion root and leaf positively changed plasma antioxidant enzyme activities and lipid profiles in cholesterol-fed rabbits, and thus may have potential hypolipidemic and antioxidant effects.
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The association of c-reactive protein, serum amyloid a and fibrinogen with prevalent coronary heart disease — baseline findings of the PAIS project
TL;DR: The hypothesis that cholesterol-lowering drugs have an anti-inflammatory effect is supported, as CRP, SAA and fibrinogen, which are markers of inflammation, were positively and significantly associated with prevalent CHD.
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Periodontitis-associated up-regulation of systemic inflammatory mediator level may increase the risk of coronary heart disease.
Takako Nakajima,Tomoyuki Honda,Hisanori Domon,Takafumi Okui,K. Kajita,Harue Ito,Naoki Takahashi,Tomoki Maekawa,Koichi Tabeta,Kazuhisa Yamazaki +9 more
TL;DR: Although periodontal infection does affect the concentration of hs-CRP and IL-6 in serum, a subgroup of patients exist who are highly susceptible to an increased risk ofCHD associated with periodontitis, suggesting that there may be subjects who have an elevated risk of CHD independent of susceptibility toperiodontal tissue destruction per se.
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Leptin Increases Lipoprotein Lipase Secretion by Macrophages: Involvement of Oxidative Stress and Protein Kinase C
TL;DR: Binding of leptin at the macrophage cell surface increases, through oxidative stress- and PKC-dependent pathways, LPL expression, and this effect appears to be exerted at the transcriptional level and to involve AP-1 activation.
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Purification of novel anti-inflammatory peptides from enzymatic hydrolysate of the edible microalgal Spirulina maxima
TL;DR: It was found that peptides P1 and P2 exhibited significant inhibition on the release and production of histamine from antigen-stimulated RBL-2H3 mast cells, and could be used as functional ingredients with potent anti-inflammatory benefits.
References
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The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
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Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
J. Shepherd,Stuart M. Cobbe,Ian Ford,C. G. Isles,AR Lorimer,Peter W. Macfarlane,J. H. Mckillop,Christopher J. Packard +7 more
TL;DR: Treatment with pravastatin significantly reduced the incidence of myocardial infarction and death from cardiovascular causes without adversely affecting the risk of death from noncardiovascular causes in men with moderate hypercholesterolemia and no history of my Cardiac Infarction.
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Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
TL;DR: The reduction associated with the use of aspirin in the risk of a first myocardial infarction appears to be directly related to the level of C-reactive protein, raising the possibility that antiinflammatory agents may have clinical benefits in preventing cardiovascular disease.
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The Pathogenesis of Atherosclerosis — An Update
TL;DR: A response-to-injury hypothesis of atherogenesis proposes that "injury" to the endothelium is the initiating event in atherosclerosis, and intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of Atherosclerosis.
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Compensatory Enlargement of Human Atherosclerotic Coronary Arteries
Seymour Glagov,Elliot Weisenberg,Christopher K. Zarins,Regina Stankunavicius,George J. Kolettis +4 more
TL;DR: It is concluded that human coronary arteries enlarge in relation to plaque area and that functionally important lumen stenosis may be delayed until the lesion occupies 40 percent of the internal elastic lamina area.