Open AccessJournal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
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TLDR
Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.About:
This article is published in Japanese Circulation Journal-english Edition.The article was published on 1998-02-28 and is currently open access. It has received 9749 citations till now. The article focuses on the topics: Disease.read more
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Biochemistry and molecular cell biology of diabetic complications
TL;DR: This integrating paradigm provides a new conceptual framework for future research and drug discovery in diabetes-specific microvascular disease and seems to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain.
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C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women
TL;DR: The addition of the measurement of C-reactive protein to screening based on lipid levels may provide an improved method of identifying persons at risk for cardiovascular events.
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The metabolic syndrome
TL;DR: The pathophysiology seems to be largely attributable to insulin resistance with excessive flux of fatty acids implicated, and a proinflammatory state probably contributes to the metabolic syndrome.
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The importance of the ratio of omega-6/omega-3 essential fatty acids.
TL;DR: In this article, a lower omega-6/omega-3 ratio in women with breast cancer was associated with decreased risk, whereas a higher ratio of omega-3 PUFA had no effect.
References
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Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase
Gilbert R. Upchurch,George N. Welch,Attila J. Fabian,Jane E. Freedman,Joseph L. Johnson,John F. Keaney,Joseph Loscalzo +6 more
TL;DR: It is shown that Hcy treatment of bovine aortic endothelial cells leads to a dose-dependent decrease in NO x independent of endothelial nitric-oxide synthase activity or protein levels and nos3 transcription, suggesting that HCy affects the bioavailability of NO, not its production.
Journal Article
Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme.
Yong-Jian Geng,Peter Libby +1 more
TL;DR: Data point to a role for apoptosis in regulation of cell accumulation during atherogenesis and suggest involvement of ICE in SMC death in fibrous regions of complex atheroma, and in macrophage death in the lipid-rich core of the lesion.
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Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II.
TL;DR: This study demonstrates that Ang II induces a severalfold increase in TGF beta 1 mRNA levels within 4 h that is dependent on de novo protein synthesis and appears to be mediated by activation of protein kinase C (PKC).
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The Unstable Atheroma
Richard T. Lee,Peter Libby +1 more
TL;DR: It is proposed that the basic biology of the unstable lesion will now assume even greater importance for two fundamental reasons: first, even with aspirin and cholesterol-lowering therapy, acute vascular events will continue to be a major cause of morbidity and mortality in developed countries.
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Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element.
TL;DR: The expression of PDGF-B and other pathophysiologically relevant genes in vascular endothelium appears to be regulated, in part, by shear-stress-induced transcription factors interacting with a common promoter element.