Open AccessJournal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
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TLDR
Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.About:
This article is published in Japanese Circulation Journal-english Edition.The article was published on 1998-02-28 and is currently open access. It has received 9749 citations till now. The article focuses on the topics: Disease.read more
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Atherosclerosis: the emerging role of inflammation and the CD40-CD40 ligand system.
TL;DR: Evidence of disruption of the CD40–CD40 ligand (L) system, a key mediator of cell communication in the immune system, prevents progression of established atherosclerotic lesions to more advanced unstable lesions, provides compelling evidence for the role of chronic inflammation and elements of the immune response in atherosclerosis.
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Drug-Eluting Stents
T Cooper Woods,Andrew R. Marks +1 more
TL;DR: It has become clear that in-stent restenosis is largely due to the migration and proliferation of vascular smooth muscle cells to form a neointima, and stents coated with drug-delivery vehicles have been developed to deliver antiproliferative therapeutics.
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A novel drug-eluting stent coated with an integrin-binding cyclic Arg-Gly-Asp peptide inhibits neointimal hyperplasia by recruiting endothelial progenitor cells.
Rüdiger Blindt,Felix Vogt,Irina Astafieva,Christian Fach,Mihail Hristov,Nicole Krott,Berthold Seitz,Aphrodite Kapurniotu,Connie Kwok,Manfred Dewor,Anja-Katrin Bosserhoff,Jürgen Bernhagen,Peter Hanrath,Rainer Hoffmann,Christian Weber +14 more
TL;DR: Novel stents loaded with an integrin-binding cyclic Arg-Gly-Asp peptide (cRGD) were analyzed for their potential to limit coronary neointima formation and to accelerate endothelialization by attracting endothelial progenitor cells (EPCs).
Journal ArticleDOI
Structural identification of a novel pro-inflammatory epoxyisoprostane phospholipid in mildly oxidized low density lipoprotein
Andrew D. Watson,Ganesamoorthy Subbanagounder,Derek S. Welsbie,Kym F. Faull,Mohamad Navab,Michael E. Jung,Alan M. Fogelman,Judith A. Berliner +7 more
TL;DR: The fragmentation pattern produced by electrospray ionization-collision induced dissociation-tandem mass spectrometry was consistent with a molecule resembling an E-ring prostaglandin with an epoxide at the 5,6 position, adding epoxyisoprostane E2 to the growing list of biologically active isoprostanes.
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Methods and application areas of endoscopic optical coherence tomography
TL;DR: The current state of research in endoscopic optical coherence tomography (OCT) is reviewed, and the reported utility of the methods in digestive, intravascular, respiratory, urinary and reproductive systems is examined.
References
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Journal ArticleDOI
The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
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Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
J. Shepherd,Stuart M. Cobbe,Ian Ford,C. G. Isles,AR Lorimer,Peter W. Macfarlane,J. H. Mckillop,Christopher J. Packard +7 more
TL;DR: Treatment with pravastatin significantly reduced the incidence of myocardial infarction and death from cardiovascular causes without adversely affecting the risk of death from noncardiovascular causes in men with moderate hypercholesterolemia and no history of my Cardiac Infarction.
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Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
TL;DR: The reduction associated with the use of aspirin in the risk of a first myocardial infarction appears to be directly related to the level of C-reactive protein, raising the possibility that antiinflammatory agents may have clinical benefits in preventing cardiovascular disease.
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The Pathogenesis of Atherosclerosis — An Update
TL;DR: A response-to-injury hypothesis of atherogenesis proposes that "injury" to the endothelium is the initiating event in atherosclerosis, and intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of Atherosclerosis.
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Compensatory Enlargement of Human Atherosclerotic Coronary Arteries
Seymour Glagov,Elliot Weisenberg,Christopher K. Zarins,Regina Stankunavicius,George J. Kolettis +4 more
TL;DR: It is concluded that human coronary arteries enlarge in relation to plaque area and that functionally important lumen stenosis may be delayed until the lesion occupies 40 percent of the internal elastic lamina area.