Open AccessJournal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
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TLDR
Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.About:
This article is published in Japanese Circulation Journal-english Edition.The article was published on 1998-02-28 and is currently open access. It has received 9749 citations till now. The article focuses on the topics: Disease.read more
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Oral inflammation and infection, and chronic medical diseases: implications for the elderly
TL;DR: There is moderate evidence that improved oral hygiene may help prevent aspiration pneumonia in high-risk patients, and no specific guidance can be provided regarding oral hygiene or periodontal interventions that enhance the medical management of older adults.
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Socioeconomic status and stress-induced increases in interleukin-6
TL;DR: It is suggested that low SES people are less able to adapt to stress than their high SES counterparts, and prolonged stress-induced increases in IL-6 in low S ES groups represents a novel mechanism potentially linking socioeconomic position and heart disease.
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Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic root
Daniel Teupser,Stephanos Pavlides,Marietta Tan,Jose-Carlos Gutierrez-Ramos,Roland Kolbeck,Jan L. Breslow +5 more
TL;DR: It is concluded that the major reduction of atherosclerosis in fractalkine-deficient mice appears to be at the BCA rather than the aortic root.
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Dietary polyphenols: Structures, bioavailability and protective effects against atherosclerosis.
TL;DR: Emerging data suggest that polyphenols can regulate cellular lipid metabolism; vascular and endothelial function; haemostasis; as well as platelet function; which represent primary conditions for atherosclerotic plaque formation and development.
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Infectious Complications in Chronic Kidney Disease
Sakina B. Naqvi,Allan J. Collins +1 more
TL;DR: CKD is associated with significant major infectious complications, which occur at rates 3 to 4 times the general population, and providers can improve prevention by using fewer dialysis catheters and increasing vaccination rates for influenza and pneumococcal pneumonia.
References
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The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
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Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
J. Shepherd,Stuart M. Cobbe,Ian Ford,C. G. Isles,AR Lorimer,Peter W. Macfarlane,J. H. Mckillop,Christopher J. Packard +7 more
TL;DR: Treatment with pravastatin significantly reduced the incidence of myocardial infarction and death from cardiovascular causes without adversely affecting the risk of death from noncardiovascular causes in men with moderate hypercholesterolemia and no history of my Cardiac Infarction.
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Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
TL;DR: The reduction associated with the use of aspirin in the risk of a first myocardial infarction appears to be directly related to the level of C-reactive protein, raising the possibility that antiinflammatory agents may have clinical benefits in preventing cardiovascular disease.
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The Pathogenesis of Atherosclerosis — An Update
TL;DR: A response-to-injury hypothesis of atherogenesis proposes that "injury" to the endothelium is the initiating event in atherosclerosis, and intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of Atherosclerosis.
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Compensatory Enlargement of Human Atherosclerotic Coronary Arteries
Seymour Glagov,Elliot Weisenberg,Christopher K. Zarins,Regina Stankunavicius,George J. Kolettis +4 more
TL;DR: It is concluded that human coronary arteries enlarge in relation to plaque area and that functionally important lumen stenosis may be delayed until the lesion occupies 40 percent of the internal elastic lamina area.