Open AccessJournal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
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TLDR
Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.About:
This article is published in Japanese Circulation Journal-english Edition.The article was published on 1998-02-28 and is currently open access. It has received 9749 citations till now. The article focuses on the topics: Disease.read more
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Journal ArticleDOI
Systemic markers of inflammation and cognitive decline in old age
Miranda T. Schram,Sjoerd M. Euser,Anton J. M. de Craen,Jacqueline C. M. Witteman,Marijke Frölich,Albert Hofman,J. Jolles,Monique M.B. Breteler,Rudi G. J. Westendorp +8 more
TL;DR: In this article, the authors investigated whether higher circulating levels of C-reactive protein (CRP), interleukin-6 (IL-6), and a1-antichymotrypsin (ACT) are associated with worse cognitive function and decline in old age.
Journal ArticleDOI
Inflammation in carotid atherosclerotic plaque: a dynamic contrast-enhanced MR imaging study.
William S. Kerwin,Kevin D. O'Brien,Marina S. Ferguson,Nayak L. Polissar,Thomas S. Hatsukami,Chun Yuan +5 more
TL;DR: The correlations between Ktrans and histologic markers of inflammation suggest that Ktrans is a quantitative and noninvasive marker of plaque inflammation, which is further supported by the correlation of Ktrans with proinflammatory cardiovascular risk factors, decreased high-density lipoprotein levels, and smoking.
Journal ArticleDOI
Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling
Shaw-Fang Yet,Matthew D. Layne,Xiaoli Liu,Yen-Hsu Chen,Yen-Hsu Chen,Bonna Ith,Nicholas E.S. Sibinga,Mark A. Perrella +7 more
TL;DR: The data demonstrate that HO‐1 plays an essential protective role in the pathophysiology of atherosclerosis and vein graft stenosis.
Journal ArticleDOI
Insulin resistance and atherosclerosis
TL;DR: This review addresses the metabolic consequences of the insulin resistance syndrome, its relationship with Atherosclerosis, and the impact of insulin resistance on processes of atherosclerosis including insulin signaling in cells of the vasculature.
Book ChapterDOI
Heat shock proteins as ligands of toll-like receptors.
TL;DR: Human HSP60 and Gp96 are the first examples of non-pathogen derived ligands of TLRs and provides the first example of how the innate and adaptive immune system can be stimulated simultaneously by the same molecule which is released under physiological conditions from necrotic cells.
References
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The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
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Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
J. Shepherd,Stuart M. Cobbe,Ian Ford,C. G. Isles,AR Lorimer,Peter W. Macfarlane,J. H. Mckillop,Christopher J. Packard +7 more
TL;DR: Treatment with pravastatin significantly reduced the incidence of myocardial infarction and death from cardiovascular causes without adversely affecting the risk of death from noncardiovascular causes in men with moderate hypercholesterolemia and no history of my Cardiac Infarction.
Journal ArticleDOI
Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
TL;DR: The reduction associated with the use of aspirin in the risk of a first myocardial infarction appears to be directly related to the level of C-reactive protein, raising the possibility that antiinflammatory agents may have clinical benefits in preventing cardiovascular disease.
Journal ArticleDOI
The Pathogenesis of Atherosclerosis — An Update
TL;DR: A response-to-injury hypothesis of atherogenesis proposes that "injury" to the endothelium is the initiating event in atherosclerosis, and intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of Atherosclerosis.
Journal ArticleDOI
Compensatory Enlargement of Human Atherosclerotic Coronary Arteries
Seymour Glagov,Elliot Weisenberg,Christopher K. Zarins,Regina Stankunavicius,George J. Kolettis +4 more
TL;DR: It is concluded that human coronary arteries enlarge in relation to plaque area and that functionally important lumen stenosis may be delayed until the lesion occupies 40 percent of the internal elastic lamina area.