Open AccessJournal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
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TLDR
Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.About:
This article is published in Japanese Circulation Journal-english Edition.The article was published on 1998-02-28 and is currently open access. It has received 9749 citations till now. The article focuses on the topics: Disease.read more
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Nitric Oxide Cytoskeletal–Induced Alterations Reverse the Endothelial Progenitor Cell Migratory Defect Associated With Diabetes
Mark S. Segal,Ronak Shah,Aqeela Afzal,Cecile M. Perrault,Kyung Hee Chang,Anna Schuler,Elaine Beem,Lynn C. Shaw,Sergio Li Calzi,Jeffrey K. Harrison,Roger Tran-Son-Tay,Maria B. Grant +11 more
TL;DR: It is described that picomolar and nanomolar concentrations of SDF-1 differentially influence neovascularization, inducing CD34+ cell migration and EPC tube formation and exogenous NO alters vasodilator-stimulated phosphoprotein and mammalian-enabled distribution in EPCs.
Journal ArticleDOI
Therapeutic potential of nanoparticulate systems for macrophage targeting.
TL;DR: An overview of the usefulness of nanoparticles for macrophage-mediated therapies in particular is presented and the most important parameters that affect the interaction mechanisms of the macrophages and the physicochemical aspects of the particulate systems that may influence their performance in macophage-targeted therapies are underlined.
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A prospective evaluation of lipoprotein-associated phospholipase A2levels and the risk of future cardiovascular events in women☆
TL;DR: The current data suggest that Lp-PLA(2) is not a strong predictor of future cardiovascular risk among unselected women, in contrast to prior data among hyperlipidemic men.
Journal ArticleDOI
Low vagal tone is associated with impaired post stress recovery of cardiovascular, endocrine, and immune markers
Cora Weber,Julian F. Thayer,Julian F. Thayer,M. Rudat,Petra H. Wirtz,Frank Zimmermann-Viehoff,Alexander Thomas,Frank H. Perschel,Petra C. Arck,Hans Christian Deter +9 more
TL;DR: Low vagal tone was associated with impaired recovery of cardiovascular, endocrine, and immune markers in healthy males, and the data support an inhibitory role of the vagus in the regulation of allostatic systems as described in the neurovisceral integration model.
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Sphingosine-1-Phosphate, a Platelet-Derived Lysophospholipid Mediator, Negatively Regulates Cellular Rac Activity and Cell Migration in Vascular Smooth Muscle Cells
Yasuji Ryu,Noriko Takuwa,Naotoshi Sugimoto,Sotaro Sakurada,Soichiro Usui,Hiroyuki Okamoto,Osamu Matsui,Yoh Takuwa +7 more
TL;DR: Edg isoform-specific, negative or positive regulation of cellular Rac activity is critically involved in S1P-mediated bimodal regulation of cell motility in SMCs and HUVECs.
References
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Journal ArticleDOI
The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
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Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
J. Shepherd,Stuart M. Cobbe,Ian Ford,C. G. Isles,AR Lorimer,Peter W. Macfarlane,J. H. Mckillop,Christopher J. Packard +7 more
TL;DR: Treatment with pravastatin significantly reduced the incidence of myocardial infarction and death from cardiovascular causes without adversely affecting the risk of death from noncardiovascular causes in men with moderate hypercholesterolemia and no history of my Cardiac Infarction.
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Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
TL;DR: The reduction associated with the use of aspirin in the risk of a first myocardial infarction appears to be directly related to the level of C-reactive protein, raising the possibility that antiinflammatory agents may have clinical benefits in preventing cardiovascular disease.
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The Pathogenesis of Atherosclerosis — An Update
TL;DR: A response-to-injury hypothesis of atherogenesis proposes that "injury" to the endothelium is the initiating event in atherosclerosis, and intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of Atherosclerosis.
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Compensatory Enlargement of Human Atherosclerotic Coronary Arteries
Seymour Glagov,Elliot Weisenberg,Christopher K. Zarins,Regina Stankunavicius,George J. Kolettis +4 more
TL;DR: It is concluded that human coronary arteries enlarge in relation to plaque area and that functionally important lumen stenosis may be delayed until the lesion occupies 40 percent of the internal elastic lamina area.