Open AccessJournal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
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TLDR
Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.About:
This article is published in Japanese Circulation Journal-english Edition.The article was published on 1998-02-28 and is currently open access. It has received 9749 citations till now. The article focuses on the topics: Disease.read more
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Differences in risk factors, atherosclerosis, and cardiovascular disease between ethnic groups in Canada: the Study of Health Assessment and Risk in Ethnic groups (SHARE)
Sonia S. Anand,Salim Yusuf,Vladmir Vuksan,Sudarshan Devanesen,Koon K. Teo,Patricia A Montague,Linda E. Kelemen,Cheelong Yi,Eva Lonn,Hertzel C. Gerstein,Robert A. Hegele,Matthew J. McQueen +11 more
TL;DR: In this article, the authors conducted a population-based study of three ethnic groups in Canada: South Asians, Chinese, and Europeans, and found that the degree of carotid atherosclerosis was associated with a higher prevalence of cardiovascular disease.
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Why Are Patients With Chronic Obstructive Pulmonary Disease at Increased Risk of Cardiovascular Diseases? The Potential Role of Systemic Inflammation in Chronic Obstructive Pulmonary Disease
Don D. Sin,S. F. Paul Man +1 more
TL;DR: Low-grade systemic inflammation was present in participants with moderate to severe airflow obstruction and was associated with increased risk of cardiac injury, which may in part explain the high rates of cardiovascular complications in COPD.
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Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E
Kathrin S. Michelsen,Michelle H. Wong,Prediman K. Shah,Wenxuan Zhang,Juliana Yano,Terence M. Doherty,Shizuo Akira,Tripathi B. Rajavashisth,Moshe Arditi +8 more
TL;DR: An important role for TLR4 and MyD88 signaling in atherosclerosis in a hypercholesterolemic mouse model is suggested, providing a pathophysiologic link between innate immunity, inflammation, and atherogenesis.
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Omega‐3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?
TL;DR: Animal models demonstrate benefit from n-3 fatty acids in rheumatoid arthritis (RA), inflammatory bowel disease (IBD) and asthma, and clinical trails of fish oil in patients with IBD and asthma are inconsistent with no overall clear evidence of efficacy.
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Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids
TL;DR: Research has shown that reductions may be achieved in the incidence of many chronic diseases that involve inflammatory processes; most notably, these include cardiovascular diseases, inflammatory bowel disease (IBD), cancer, and rheumatoid arthritis, but psychiatric and neurodegenerative illnesses are other examples.
References
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The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
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Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
J. Shepherd,Stuart M. Cobbe,Ian Ford,C. G. Isles,AR Lorimer,Peter W. Macfarlane,J. H. Mckillop,Christopher J. Packard +7 more
TL;DR: Treatment with pravastatin significantly reduced the incidence of myocardial infarction and death from cardiovascular causes without adversely affecting the risk of death from noncardiovascular causes in men with moderate hypercholesterolemia and no history of my Cardiac Infarction.
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Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
TL;DR: The reduction associated with the use of aspirin in the risk of a first myocardial infarction appears to be directly related to the level of C-reactive protein, raising the possibility that antiinflammatory agents may have clinical benefits in preventing cardiovascular disease.
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The Pathogenesis of Atherosclerosis — An Update
TL;DR: A response-to-injury hypothesis of atherogenesis proposes that "injury" to the endothelium is the initiating event in atherosclerosis, and intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of Atherosclerosis.
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Compensatory Enlargement of Human Atherosclerotic Coronary Arteries
Seymour Glagov,Elliot Weisenberg,Christopher K. Zarins,Regina Stankunavicius,George J. Kolettis +4 more
TL;DR: It is concluded that human coronary arteries enlarge in relation to plaque area and that functionally important lumen stenosis may be delayed until the lesion occupies 40 percent of the internal elastic lamina area.