Open AccessJournal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
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TLDR
Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.About:
This article is published in Japanese Circulation Journal-english Edition.The article was published on 1998-02-28 and is currently open access. It has received 9749 citations till now. The article focuses on the topics: Disease.read more
Citations
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Matrix-specific suppression of integrin activation in shear stress signaling.
TL;DR: It is shown that flow activates ECM-specific signals that establish patterns of integrin dominance, which may determine cellular responses to complex extracellular matrices.
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Cardiovascular disease determinants in chronic renal failure: clinical approach and treatment
Francesco Locatelli,Jürgen Bommer,Gérard M. London,Alejandro Martin-Malo,Christoph Wanner,Mohammed Yaqoob,Carmine Zoccali +6 more
TL;DR: Convective dialysis treatments may confer some degree of protection from dialysis-related amyloidosis and mortality, but clinical data on this important issue are still controversial and no definitive conclusions can be drawn at present.
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Elevated levels of small, low-density lipoprotein with high affinity for arterial matrix components in patients with rheumatoid arthritis: possible contribution of phospholipase A2 to this atherogenic profile.
Eva Hurt-Camejo,Silvia Paredes,Lluís Masana,Germán Camejo,Peter Sartipy,Birgitta Rosengren,Javier Pedreño,Joan-Carles Vallvé,Pere Benito,Olov Wiklund +9 more
TL;DR: These atherogenic lipoprotein factors combined with the presence of chronic inflammation may contribute to the high CVD-related mortality in RA patients.
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Endothelial dysfunction in metabolic syndrome: Prevalence, pathogenesis and management
TL;DR: It remains to be established whether improving endothelial function in MetS will reduce the risk for type 2 diabetes mellitus and vascular events.
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Statins as potential therapeutic agents in neuroinflammatory disorders.
TL;DR: Results from in-vivo animal models suggest that statins may be beneficial in treatment of different central nervous system conditions, and larger scale, randomized, double-blind trials are needed to validate the role of statins as a treatment of inflammatory central nervous System diseases.
References
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The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
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Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
J. Shepherd,Stuart M. Cobbe,Ian Ford,C. G. Isles,AR Lorimer,Peter W. Macfarlane,J. H. Mckillop,Christopher J. Packard +7 more
TL;DR: Treatment with pravastatin significantly reduced the incidence of myocardial infarction and death from cardiovascular causes without adversely affecting the risk of death from noncardiovascular causes in men with moderate hypercholesterolemia and no history of my Cardiac Infarction.
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Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
TL;DR: The reduction associated with the use of aspirin in the risk of a first myocardial infarction appears to be directly related to the level of C-reactive protein, raising the possibility that antiinflammatory agents may have clinical benefits in preventing cardiovascular disease.
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The Pathogenesis of Atherosclerosis — An Update
TL;DR: A response-to-injury hypothesis of atherogenesis proposes that "injury" to the endothelium is the initiating event in atherosclerosis, and intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of Atherosclerosis.
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Compensatory Enlargement of Human Atherosclerotic Coronary Arteries
Seymour Glagov,Elliot Weisenberg,Christopher K. Zarins,Regina Stankunavicius,George J. Kolettis +4 more
TL;DR: It is concluded that human coronary arteries enlarge in relation to plaque area and that functionally important lumen stenosis may be delayed until the lesion occupies 40 percent of the internal elastic lamina area.