Open AccessJournal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
Reads0
Chats0
TLDR
Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.About:
This article is published in Japanese Circulation Journal-english Edition.The article was published on 1998-02-28 and is currently open access. It has received 9749 citations till now. The article focuses on the topics: Disease.read more
Citations
More filters
Journal ArticleDOI
Biochemistry and molecular cell biology of diabetic complications
TL;DR: This integrating paradigm provides a new conceptual framework for future research and drug discovery in diabetes-specific microvascular disease and seems to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain.
Journal ArticleDOI
C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women
TL;DR: The addition of the measurement of C-reactive protein to screening based on lipid levels may provide an improved method of identifying persons at risk for cardiovascular events.
Journal ArticleDOI
The metabolic syndrome
TL;DR: The pathophysiology seems to be largely attributable to insulin resistance with excessive flux of fatty acids implicated, and a proinflammatory state probably contributes to the metabolic syndrome.
Journal ArticleDOI
The importance of the ratio of omega-6/omega-3 essential fatty acids.
TL;DR: In this article, a lower omega-6/omega-3 ratio in women with breast cancer was associated with decreased risk, whereas a higher ratio of omega-3 PUFA had no effect.
References
More filters
Journal ArticleDOI
Cytokine regulation of low density lipoprotein receptor gene transcription in HepG2 cells.
TL;DR: It is proposed that TNF and IL-1, acting via distinct signal transduction pathways, increase surface LDL receptors by increasing gene transcription, and suggest that cytokine-induced hypocholesterolemia may be related to T NF and/orIL-1 stimulation of hepatic LDL receptor gene expression and function.
Journal ArticleDOI
Endothelium-dependent responses in hypertension.
TL;DR: The endothelium dysfunction observed in hypertensive blood vessels is likely to be a consequence rather than a cause of the disease process.
Journal Article
Virus-induced atherosclerosis. Herpesvirus infection alters aortic cholesterol metabolism and accumulation.
TL;DR: Results suggest that lipid accretion in aortas of MDV-infected chickens results, in part, from alterations in cholesterol/CE metabolism during early stages of the disease.
Journal ArticleDOI
Fibrinogen and Silent Atherosclerosis in Subjects With Cardiovascular Risk Factors
TL;DR: The association between fibrinogen levels and atherosclerotic plaques over three different arterial sites in an asymptomatic never-treated male population with increased cardiovascular risk was assessed and multiple regression analysis indicated independent associations between fibinogen and the presence and extent of atherosclerosis.