Open AccessJournal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
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TLDR
Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.About:
This article is published in Japanese Circulation Journal-english Edition.The article was published on 1998-02-28 and is currently open access. It has received 9749 citations till now. The article focuses on the topics: Disease.read more
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Biochemistry and molecular cell biology of diabetic complications
TL;DR: This integrating paradigm provides a new conceptual framework for future research and drug discovery in diabetes-specific microvascular disease and seems to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain.
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C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women
TL;DR: The addition of the measurement of C-reactive protein to screening based on lipid levels may provide an improved method of identifying persons at risk for cardiovascular events.
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The metabolic syndrome
TL;DR: The pathophysiology seems to be largely attributable to insulin resistance with excessive flux of fatty acids implicated, and a proinflammatory state probably contributes to the metabolic syndrome.
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The importance of the ratio of omega-6/omega-3 essential fatty acids.
TL;DR: In this article, a lower omega-6/omega-3 ratio in women with breast cancer was associated with decreased risk, whereas a higher ratio of omega-3 PUFA had no effect.
References
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Smooth Muscle Lineage Diversity in the Chick Embryo
Stavros Topouzis,Mark W. Majesky +1 more
TL;DR: The results show that Ect and Mes SMCs exhibit lineage-dependent differences in growth and receptor-mediated transcriptional responses to at least one important class of SMC morphogens and growth modifiers, e.g., the TGF-betas.
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Native and Modified Low Density Lipoproteins Increase the Functional Expression of the Macrophage Class B Scavenger Receptor, CD36 *
TL;DR: Exposure to free and esterified lipids augments functional expression of the class B scavenger receptor, CD36, and implies that lipoproteins can further contribute to foam cell development in atherosclerosis by up-regulating a major OxLDL receptor.
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Atherosclerotic lesions in humans. In situ immunophenotypic analysis suggesting an immune mediated response.
TL;DR: Observations suggest that a specific in situ immune mediated hypersensitivity reaction is associated with the development of atherosclerosis.
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Prelesional events in atherogenesis: accumulation of extracellular cholesterol-rich liposomes in the arterial intima and cardiac valves of the hyperlipidemic rabbit
TL;DR: The results show that an early prelesional ultrastructural change in lesion-prone aortic and valvular areas is the accumulation of extracellular phospholipid liposomes rich in unesterified cholesterol.
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Homocysteine as a Risk Factor for Vascular Disease: Enhanced Collagen Production and Accumulation by Smooth Muscle Cells
TL;DR: Results indicate a cellular mechanism for the atherogenicity of homocysteine and provide insight into a potential preventive treatment.