Open AccessJournal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
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TLDR
Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.About:
This article is published in Japanese Circulation Journal-english Edition.The article was published on 1998-02-28 and is currently open access. It has received 9749 citations till now. The article focuses on the topics: Disease.read more
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Chemokines and atherosclerosis.
Yuri Sheikine,Göran K. Hansson +1 more
TL;DR: In vivo and in vitro investigations showed that chemokines are produced by a variety of cells and play important roles in the development and progression of many physiological and pathological conditions including atherosclerosis, which may provide important anti‐atherogenic strategies.
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Premature atherosclerotic cardiovascular disease in systemic lupus erythematosus
Peter E. Westerweel,Remco K. M. A. C. Luyten,Hein A. Koomans,Ronald H. W. M. Derksen,Marianne C. Verhaar +4 more
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Does childhood nutrition influence adult cardiovascular disease risk?--insights from the Young Finns Study.
Jari Kaikkonen,Vera Mikkilä,Costan G. Magnussen,Markus Juonala,Jorma Viikari,Olli T. Raitakari +5 more
TL;DR: The data demonstrate that dietary patterns can already be identified in childhood and associate with cardiovascular risk factors and vascular markers of subclinical atherosclerosis and suggest that childhood nutrition has a significant role in the progression of CVD.
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Relation of inflammation to vascular function in patients with coronary heart disease.
Juha Sinisalo,J Paronen,Kimmo Mattila,Martti Syrjälä,Georg Alfthan,Timo Palosuo,Markku S. Nieminen,Outi Vaarala +7 more
TL;DR: The present data showed an association between inflammatory risk factors linked to atherothrombosis and endothelial dysfunction in coronary heart disease patients, and it is possible that endothelium dysfunction in cardiac patients is related to the chronic inflammation or infection coexisting with atherosclerosis.
Journal Article
The serum levels of growth factors: PDGF, TGF-beta and VEGF are increased after strenuous physical exercise.
TL;DR: The results point to the potentially deleterious effect of strenuous physical exercise on growth factors generation in healthy young people in the context of the role of inflammation in the pathogenesis of various diseases.
References
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The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
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Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
J. Shepherd,Stuart M. Cobbe,Ian Ford,C. G. Isles,AR Lorimer,Peter W. Macfarlane,J. H. Mckillop,Christopher J. Packard +7 more
TL;DR: Treatment with pravastatin significantly reduced the incidence of myocardial infarction and death from cardiovascular causes without adversely affecting the risk of death from noncardiovascular causes in men with moderate hypercholesterolemia and no history of my Cardiac Infarction.
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Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
TL;DR: The reduction associated with the use of aspirin in the risk of a first myocardial infarction appears to be directly related to the level of C-reactive protein, raising the possibility that antiinflammatory agents may have clinical benefits in preventing cardiovascular disease.
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The Pathogenesis of Atherosclerosis — An Update
TL;DR: A response-to-injury hypothesis of atherogenesis proposes that "injury" to the endothelium is the initiating event in atherosclerosis, and intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of Atherosclerosis.
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Compensatory Enlargement of Human Atherosclerotic Coronary Arteries
Seymour Glagov,Elliot Weisenberg,Christopher K. Zarins,Regina Stankunavicius,George J. Kolettis +4 more
TL;DR: It is concluded that human coronary arteries enlarge in relation to plaque area and that functionally important lumen stenosis may be delayed until the lesion occupies 40 percent of the internal elastic lamina area.