Open AccessJournal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
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TLDR
Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.About:
This article is published in Japanese Circulation Journal-english Edition.The article was published on 1998-02-28 and is currently open access. It has received 9749 citations till now. The article focuses on the topics: Disease.read more
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Complement component C5a predicts future cardiovascular events in patients with advanced atherosclerosis.
Walter S. Speidl,Markus Exner,Jasmin Amighi,Stefan P. Kastl,Gerlinde Zorn,Gerald Maurer,Oswald Wagner,Kurt Huber,Erich Minar,Johann Wojta,Martin Schillinger +10 more
TL;DR: Clinically, determination of C5a may add to the predictive value of other non-specific inflammatory parameters, and seems to be associated with increased cardiovascular risk in patients with advanced atherosclerosis.
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Heme, heme oxygenase and ferritin in vascular endothelial cell injury.
József Balla,Gregory M. Vercellotti,Viktória Jeney,Akihiro Yachie,Zsuzsa Varga,John W. Eaton,György Balla +6 more
TL;DR: Upon exposure to heme or hemoglobin, endothelial cells up-regulate heme oxygenase-1 and ferritin, which have been shown effective in the protection of endothelium against the damaging effects of exogenous heme and oxidants.
Journal ArticleDOI
Plasma lipoproteins promote the release of bacterial lipopolysaccharide from the monocyte cell surface.
TL;DR: Plasma immunodepletion experiments and experiments using recombinant LPS transfer proteins revealed that soluble CD14 significantly enhances LPS release from the cells, high concentrations of LPS-binding protein have a modest effect, and phospholipid transfer protein is unable to facilitate L PS release.
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Interferon-γ induces cellular senescence through p53-dependent DNA damage signaling in human endothelial cells
TL;DR: It is demonstrated that prolonged treatment with IFN-gamma induced cellular senescence in HUVECs, as confirmed by G0/G1 cell cycle arrest, up-regulation of p53 and p21 protein levels, increased SA-beta-gal staining, and the accumulation of phospho-H(2)AX foci.
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Complex Trait Analysis in the Mouse: The Strengths, The Limitations and The Promise Yet To Come
Karen J. Moore,Deborah L. Nagle +1 more
TL;DR: This article reviews use of the mouse to dissect complex genetic traits using quantitative trait analysis, with a particular emphasis on medically important diseases.
References
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The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
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Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
J. Shepherd,Stuart M. Cobbe,Ian Ford,C. G. Isles,AR Lorimer,Peter W. Macfarlane,J. H. Mckillop,Christopher J. Packard +7 more
TL;DR: Treatment with pravastatin significantly reduced the incidence of myocardial infarction and death from cardiovascular causes without adversely affecting the risk of death from noncardiovascular causes in men with moderate hypercholesterolemia and no history of my Cardiac Infarction.
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Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
TL;DR: The reduction associated with the use of aspirin in the risk of a first myocardial infarction appears to be directly related to the level of C-reactive protein, raising the possibility that antiinflammatory agents may have clinical benefits in preventing cardiovascular disease.
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The Pathogenesis of Atherosclerosis — An Update
TL;DR: A response-to-injury hypothesis of atherogenesis proposes that "injury" to the endothelium is the initiating event in atherosclerosis, and intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of Atherosclerosis.
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Compensatory Enlargement of Human Atherosclerotic Coronary Arteries
Seymour Glagov,Elliot Weisenberg,Christopher K. Zarins,Regina Stankunavicius,George J. Kolettis +4 more
TL;DR: It is concluded that human coronary arteries enlarge in relation to plaque area and that functionally important lumen stenosis may be delayed until the lesion occupies 40 percent of the internal elastic lamina area.