Open AccessJournal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
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TLDR
Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.About:
This article is published in Japanese Circulation Journal-english Edition.The article was published on 1998-02-28 and is currently open access. It has received 9749 citations till now. The article focuses on the topics: Disease.read more
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Homocysteine induces the expression of C-reactive protein via NMDAr-ROS-MAPK-NF-κB signal pathway in rat vascular smooth muscle cells.
Xiaoming Pang,Juntian Liu,Jingjing Zhao,Jun-Jun Mao,Xiaolu Zhang,Liuxin Feng,Chunjie Han,Ming Li,Shuyue Wang,Di Wu +9 more
TL;DR: Hcy is able to initiate an inflammatory response in VSMCs by stimulating CRP production, which is mediated through NMDAr-ROS-ERK1/2/p38-NF-κB signal pathway, which provides new evidence for a role of Hcy in pathogenesis of atherosclerosis.
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Cinnamaldehyde inhibits the tumor necrosis factor-α-induced expression of cell adhesion molecules in endothelial cells by suppressing NF-κB activation: Effects upon IκB and Nrf2
TL;DR: The present findings indicate that cinnamaldehyde suppresses TNF-induced singling pathways via two distinct mechanisms that are activated by different pretreatment periods, and rapidly reduces the cellular GSH levels in ECs over short term treatments but increases these levels after 9 h exposure.
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CXC and CC chemokine receptors on coronary and brain endothelia.
Omri Berger,Omri Berger,Xiaohu Gan,Xiaohu Gan,Chandrasekhar Gujuluva,Chandrasekhar Gujuluva,Alan R. Burns,Girija G. Sulur,Monique F. Stins,Dennis Way,Marlys H. Witte,Martin E. Weinand,Jonathan W. Said,Kwang Sik Kim,Dennis D. Taub,Michael C. Graves,Milan Fiala +16 more
TL;DR: The endothelia isolated from the brain display strongly both the CCR3 and CXCR4 HIV-1 coreceptors, whereas the coronary endothelias express strongly only the CX CR4 coreceptor, which could be significant with respect to the differential susceptibility of the heart and the brain to HIV- 1 invasion.
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Reduced endothelium-dependent and -independent dilation of conductance arteries in African Americans.
Umberto Campia,Wassim K Choucair,Melissa B. Bryant,Myron A. Waclawiw,Carmine Cardillo,Julio A. Panza +5 more
TL;DR: African Americans show reduced responsiveness of conductance vessels to both endogenous and exogenous NO compared with Caucasian Americans, and this findings expand the understanding of racial differences in vascular function and suggest a mechanistic explanation for the increased incidence and severity of cardiovascular disease observed in African Americans.
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Omentin plays an anti-inflammatory role through inhibition of TNF-α-induced superoxide production in vascular smooth muscle cells
TL;DR: It is suggested that omentin inhibits TNF-α-induced VCAM-1 expression via preventing the activation of p38 and JNK at least in part through inhibition of superoxide production.
References
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Journal ArticleDOI
The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
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Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group
J. Shepherd,Stuart M. Cobbe,Ian Ford,C. G. Isles,AR Lorimer,Peter W. Macfarlane,J. H. Mckillop,Christopher J. Packard +7 more
TL;DR: Treatment with pravastatin significantly reduced the incidence of myocardial infarction and death from cardiovascular causes without adversely affecting the risk of death from noncardiovascular causes in men with moderate hypercholesterolemia and no history of my Cardiac Infarction.
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Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
TL;DR: The reduction associated with the use of aspirin in the risk of a first myocardial infarction appears to be directly related to the level of C-reactive protein, raising the possibility that antiinflammatory agents may have clinical benefits in preventing cardiovascular disease.
Journal ArticleDOI
The Pathogenesis of Atherosclerosis — An Update
TL;DR: A response-to-injury hypothesis of atherogenesis proposes that "injury" to the endothelium is the initiating event in atherosclerosis, and intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of Atherosclerosis.
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Compensatory Enlargement of Human Atherosclerotic Coronary Arteries
Seymour Glagov,Elliot Weisenberg,Christopher K. Zarins,Regina Stankunavicius,George J. Kolettis +4 more
TL;DR: It is concluded that human coronary arteries enlarge in relation to plaque area and that functionally important lumen stenosis may be delayed until the lesion occupies 40 percent of the internal elastic lamina area.