Bone regenerative medicine: classic options, novel strategies, and future directions
TLDR
Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects and may open new insights in the near future.Abstract:
This review analyzes the literature of bone grafts and introduces tissue engineering as a strategy in this field of orthopedic surgery. We evaluated articles concerning bone grafts; analyzed characteristics, advantages, and limitations of the grafts; and provided explanations about bone-tissue engineering technologies. Many bone grafting materials are available to enhance bone healing and regeneration, from bone autografts to graft substitutes; they can be used alone or in combination. Autografts are the gold standard for this purpose, since they provide osteogenic cells, osteoinductive growth factors, and an osteoconductive scaffold, all essential for new bone growth. Autografts carry the limitations of morbidity at the harvesting site and limited availability. Allografts and xenografts carry the risk of disease transmission and rejection. Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects. The combined use of scaffolds, healing promoting factors, together with gene therapy, and, more recently, three-dimensional printing of tissue-engineered constructs may open new insights in the near future.read more
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Book ChapterDOI
Bone Repair and Regeneration Are Regulated by the Wnt Signaling Pathway
Khosrow Siamak Houschyar,Dominik Duscher,Zeshaan N. Maan,Malcolm P. Chelliah,Mimi R. Borrelli,Kamran Harati,Christoph Wallner,Susanne Rein,Christian Tapking,Christian Tapking,Georg Reumuth,Gerrit Grieb,F. Siemers,Marcus Lehnhardt,Björn Behr +14 more
TL;DR: The essential role of the Wnt pathway in bone regeneration is explored, suggesting that Wnt factors could be used to stimulate bone healing of nonunions and large bony defects.
Evaluasi Indeks Eritrosit Kelinci New Zealand White pada Persembuhan Tulang dengan Implantasi Bifasik Kalsium Fosfat
TL;DR: The result showed that the rabbit suffered megaloblastic anemia caused by vitamin B12 deficiencies, and both of BCP implantion were not significantly impaired erythrocyte indices of the rabbits, which indicates that BCP material can be accepted by the body.
Journal ArticleDOI
Selected mechanical properties of human cancellous bone subjected to different treatments: short-term immersion in physiological saline and acetone treatment with subsequent immersion in physiological saline
TL;DR: In this paper , the authors investigated the mechanical properties of cancellous bone subjected to short-term immersion in saline and acetone treatment with subsequent immersion in a pool of saline and found that the average E0 of acetone and saline-treated samples was significantly higher than that of non-treated ones (non-treated 62.17 ± 21.08 vs. saline-immersed 66.29 ± 20.61, p = 0.132).
References
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