Bone regenerative medicine: classic options, novel strategies, and future directions
TLDR
Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects and may open new insights in the near future.Abstract:
This review analyzes the literature of bone grafts and introduces tissue engineering as a strategy in this field of orthopedic surgery. We evaluated articles concerning bone grafts; analyzed characteristics, advantages, and limitations of the grafts; and provided explanations about bone-tissue engineering technologies. Many bone grafting materials are available to enhance bone healing and regeneration, from bone autografts to graft substitutes; they can be used alone or in combination. Autografts are the gold standard for this purpose, since they provide osteogenic cells, osteoinductive growth factors, and an osteoconductive scaffold, all essential for new bone growth. Autografts carry the limitations of morbidity at the harvesting site and limited availability. Allografts and xenografts carry the risk of disease transmission and rejection. Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects. The combined use of scaffolds, healing promoting factors, together with gene therapy, and, more recently, three-dimensional printing of tissue-engineered constructs may open new insights in the near future.read more
Citations
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Journal ArticleDOI
The osteogenic potential of human bone callus.
TL;DR: Investigation of bone callus found that it possesses osteogenic potential and can potentially serve as an alternative source of material for bone grafts and induced new bone formation in a nude mouse model.
Journal ArticleDOI
The effects of gelatin, fibrin-platelet glue and their combination on healing of the experimental critical bone defect in a rat model: radiological, histological, scanning ultrastructural and biomechanical evaluation
TL;DR: Results of present study showed that the Gel alone did not significantly affect bone healing and regeneration; however, the Gel treated defects promoted healing more than those that were left untreated (negative control) and the FPG-enhanced grafts provided a good scaffold containing numerous growth factors for proliferation of osteoinduction.
Journal ArticleDOI
Combined therapy of adipose-derived stem cells and photobiomodulation on accelerated bone healing of a critical size defect in an osteoporotic rat model
Mehrdad Asgari,Rouhallah Gazor,Mohammad-Amin Abdollahifar,Fatemeh Fadaei Fathabady,Fatemeh Zare,Mohsen Norouzian,Abdollah Amini,Armin Khosravipour,Pejman Kiani,Rahimeh B. Atashgah,Fatemehsadat Rezaei,Seyed Kamran Ghoreishi,Sufan Chien,Michael R. Hamblin,Michael R. Hamblin,Mohammad Bayat,Mohammad Bayat +16 more
TL;DR: ALN, ADS, and PBM significantly increased healed bone strength in an experimental model of DBM-treated CSFD in the catabolic phase of bone healing in osteoporotic rats.
Journal ArticleDOI
Surface-treated 3D printed Ti-6Al-4V scaffolds with enhanced bone regeneration performance: an in vivo study.
Guangdao Zhang,Pengyu Zhao,Lin Lin,Limei Qin,Zhiguang Huan,Sander Leeflang,Amir A. Zadpoor,Jie Zhou,Lin Wu +8 more
TL;DR: Assessing the therapeutic potential of 3D printed Ti-6Al-4V scaffolds with BG and MBG surface modifications for bone regeneration in a rabbit bone defect model found significantly higher volumes of regenerated bone, significantly higher values of the relevant bone morphometric parameters, clear signs of bone matrix apposition and maturation, and the evidence of progressed angiogenesis and blood vessel formation in the groups where the bioactive glass was added as a coating.
Book ChapterDOI
Innovation in nanomedicine and engineered nanomaterials for therapeutic purposes
TL;DR: This chapter highlighted the nanomedicine that does not exist without nanotoxicity, focusing then the authors' attention in the fields of the two most causes of death worldwide that is, cardiovascular disease and cancer.
References
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