Bone regenerative medicine: classic options, novel strategies, and future directions
TLDR
Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects and may open new insights in the near future.Abstract:
This review analyzes the literature of bone grafts and introduces tissue engineering as a strategy in this field of orthopedic surgery. We evaluated articles concerning bone grafts; analyzed characteristics, advantages, and limitations of the grafts; and provided explanations about bone-tissue engineering technologies. Many bone grafting materials are available to enhance bone healing and regeneration, from bone autografts to graft substitutes; they can be used alone or in combination. Autografts are the gold standard for this purpose, since they provide osteogenic cells, osteoinductive growth factors, and an osteoconductive scaffold, all essential for new bone growth. Autografts carry the limitations of morbidity at the harvesting site and limited availability. Allografts and xenografts carry the risk of disease transmission and rejection. Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects. The combined use of scaffolds, healing promoting factors, together with gene therapy, and, more recently, three-dimensional printing of tissue-engineered constructs may open new insights in the near future.read more
Citations
More filters
Journal ArticleDOI
Controlled release of NELL-1 protein from chitosan/hydroxyapatite-modified TCP particles
TL;DR: It was observed that the Chi/HA-TCP particles prepared with the 0.3% chitosan solution were able to successfully control the release of NELL-1 and maintain a slow, steady release for up to 28 days, which was significantly higher than that of the protein released from hydroxyapatite coated TCP (HA- TCP) particles.
Journal ArticleDOI
Poly(acrylic acid)-regulated Synthesis of Rod-Like Calcium Carbonate Nanoparticles for Inducing the Osteogenic Differentiation of MC3T3-E1 Cells
Wei Yang,Chenxue Yao,Cui Zhengyang,Dandan Luo,In-Seop Lee,Juming Yao,Cen Chen,Xiangdong Kong +7 more
TL;DR: Well-dispersed rod-like calcium carbonate nanoparticles with desired water dispersibility were developed which have great potential to be used in bone regeneration.
Journal Article
Suitability of the use of an elastin matrix combined with bone morphogenetic protein for the repair of cranial defects.
Renato de Moraes,Ana Maria de Guzzi Plepis,Virginia da Conceição Amaro Martins,Marco Antonio Hungaro Duarte,Murilo Priori Alcalde,Rogério Leone Buchaim,Karina Torres Pomini,Eduardo Gomes Machado,M.A.S. Munhoz,Fernando Bento Cunha,Amanda Regina Alves Calegari,Amilton Iatecola,Samantha Ketelyn Silva,Marcelo Rodrigues da Cunha +13 more
TL;DR: It was concluded that the support and delivery system formed by the elastin matrix associated with BMPs had a positive effect on the bone repair process.
Journal ArticleDOI
Role of platelet gel embedded within gelatin scaffold on healing of experimentally induced critical-sized radial bone defects in rats
TL;DR: Human PG had beneficial effects on bone regeneration, while combination of PG and Gel had no remarkable beneficial effect and PG when used alone can be regarded as a promising osteoinductive and osteoconductive option in bone tissue engineering applications.
Journal ArticleDOI
Supercritical fluid-assisted controllable fabrication of open and highly interconnected porous scaffolds for bone tissue engineering.
TL;DR: It is suggested that the fabrication of growth factor-loaded porous scaffolds prepared by the eco-friendly hybrid processing efficiently promoted the osteogenic differentiation and may have a significant potential in bone tissue engineering.
References
More filters
Journal ArticleDOI
Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures
Dennis M. Black,Steven R. Cummings,David B. Karpf,Jane A. Cauley,Desmond E. Thompson,Michael C. Nevitt,Douglas C. Bauer,Harry K. Genant,William L. Haskell,Robert Marcus,Susan M. Ott,James C. Torner,Sara A. Quandt,Theodore F. Reiss,Kristine E. Ensrud +14 more
TL;DR: Among women with low bone mass and existing vertebral fractures, alendronate is well tolerated and substantially reduces the frequency of morphometric and clinical vertebra fractures, as well as other clinical fractures.
Journal ArticleDOI
Porous scaffold design for tissue engineering
TL;DR: The integration of CTD with SFF to build designer tissue-engineering scaffolds is reviewed and the mechanical properties and tissue regeneration achieved using designer scaffolds are details.
Journal ArticleDOI
Crystal Structure and Hydrogen-Bonding System in Cellulose Iβ from Synchrotron X-ray and Neutron Fiber Diffraction
TL;DR: In this article, the crystal and molecular structure of cellulose Iβ were determined using synchrotron and neutron diffraction data recorded from oriented fibrous samples prepared by aligning cellulose microcrystals from tunicin.
Journal ArticleDOI
Recent advances on chitosan-based micro- and nanoparticles in drug delivery.
TL;DR: The present review outlines the major new findings on the pharmaceutical applications of chitosan-based micro/nanoparticulate drug delivery systems published over the past decade and discusses critically the usefulness of these systems in delivering the bioactive molecules.
Journal ArticleDOI
Biomedical applications of collagen
TL;DR: In this paper, the authors reviewed biomedical applications of collagen including the collagen film, which was developed as a matrix system for evaluation of tissue calcification and for the embedding of a single cell suspension for tumorigenic study.