Bone regenerative medicine: classic options, novel strategies, and future directions
TLDR
Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects and may open new insights in the near future.Abstract:
This review analyzes the literature of bone grafts and introduces tissue engineering as a strategy in this field of orthopedic surgery. We evaluated articles concerning bone grafts; analyzed characteristics, advantages, and limitations of the grafts; and provided explanations about bone-tissue engineering technologies. Many bone grafting materials are available to enhance bone healing and regeneration, from bone autografts to graft substitutes; they can be used alone or in combination. Autografts are the gold standard for this purpose, since they provide osteogenic cells, osteoinductive growth factors, and an osteoconductive scaffold, all essential for new bone growth. Autografts carry the limitations of morbidity at the harvesting site and limited availability. Allografts and xenografts carry the risk of disease transmission and rejection. Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects. The combined use of scaffolds, healing promoting factors, together with gene therapy, and, more recently, three-dimensional printing of tissue-engineered constructs may open new insights in the near future.read more
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Book ChapterDOI
Supercritical Carbon Dioxide Facilitated Collagen Scaffold Production for Tissue Engineering
TL;DR: In this article , the role of supercritical carbon dioxide extraction technology in the production of collagen scaffold biomaterials from various tissues and organs and relate it to the traditional decellularization techniques in the synthesis of collagen biomaterial for tissue and organ restoration.
Book ChapterDOI
Material Synthesis, Structures and Characterization
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Journal ArticleDOI
BMP-6 promotes type 2 immune response during enhancement of rat mandibular bone defect healing
Logan F. McColl,Xizhao Chen,Michael D. Solga,Kailo H. Schlegel,Sean P. Haughey,Peter I. Lobo,Kristen I Fread,Eli R. Zunder,Ryan Cha,Stephen J. Park,Jeanette Christophel,Quanjun Cui,Abhijit S. Dighe +12 more
TL;DR: In this article , the authors used permutations of BMP-6 (B), vascular endothelial growth factor (V), and Hedgehog signaling pathway activator smoothened agonist (S), to treat a rat mandibular defect and investigated healing outcomes at week 8, in correlation with the cellular landscape of the immune cells in the fracture callus.
Journal ArticleDOI
Comparison of Low and High Temperature Sintering for Processing of Bovine Bone as Block Grafts for Oral Use: A Biological and Mechanical In Vitro Study
TL;DR: In this paper , the authors assess bovine bone blocks at different sintering temperatures and measure the effects on mechanical properties and biocompatibility, showing that higher temperature sinterings removed all organic material (0.02% organic components and residual organic components remained) and increased crystallinity (95.33%) compared to groups 1-3.
References
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