Bone regenerative medicine: classic options, novel strategies, and future directions
TLDR
Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects and may open new insights in the near future.Abstract:
This review analyzes the literature of bone grafts and introduces tissue engineering as a strategy in this field of orthopedic surgery. We evaluated articles concerning bone grafts; analyzed characteristics, advantages, and limitations of the grafts; and provided explanations about bone-tissue engineering technologies. Many bone grafting materials are available to enhance bone healing and regeneration, from bone autografts to graft substitutes; they can be used alone or in combination. Autografts are the gold standard for this purpose, since they provide osteogenic cells, osteoinductive growth factors, and an osteoconductive scaffold, all essential for new bone growth. Autografts carry the limitations of morbidity at the harvesting site and limited availability. Allografts and xenografts carry the risk of disease transmission and rejection. Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects. The combined use of scaffolds, healing promoting factors, together with gene therapy, and, more recently, three-dimensional printing of tissue-engineered constructs may open new insights in the near future.read more
Citations
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3D Scaffolds of Polycaprolactone/Copper-Doped Bioactive Glass: Architecture Engineering with Additive Manufacturing and Cellular Assessments in a Coculture of Bone Marrow Stem Cells and Endothelial Cells.
Xiaoju Wang,Binbin Zhang Molino,Sanna Pitkänen,Miina Ojansivu,Chunlin Xu,Markus Hannula,Jari Hyttinen,Susanna Miettinen,Leena Hupa,Gordon G. Wallace +9 more
TL;DR: The cytocompatibility of the PCL/Cu-BaG scaffolds was assessed in human bone marrow stem cell (hBMSC) culture, and a dose-dependent cytotoxicity of Cu2+ was observed, indicating the potent angiogenic effect of the released Cu2+.
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Osteoarthritis of the hip and knee in former male professional soccer players.
TL;DR: Preventive training programmes should be developed to reduce the number of fPSa presenting early OA, and the prevalence rate of OA of both hip and knee is significantly higher compared to age and sex matched controls.
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Bone Regenerative Medicine in Oral and Maxillofacial Region Using a Three-Dimensional Printer*
TL;DR: Bone grafts currently used for the treatment of large bone defect or asymmetry in oral and maxillofacial region include autologous, allogeneic, and artificial bones.
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Man as a living bioreactor: Long-term histological aspects of a mandibular replacement engineered in the patient's own body.
TL;DR: Reconstruction of a mandibular discontinuity defect using a custom-made bone transplant that had been prefabricated in the gastrocolic omentum using tissue engineering strategies showed an increased amount of vital mineralized bone tissue after 10months, in comparison to biopsies obtained earlier.
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A comparison study on the behavior of human endometrial stem cell-derived osteoblast cells on PLGA/HA nanocomposite scaffolds fabricated by electrospinning and freeze-drying methods
Mojdeh Salehi Namini,Neda Bayat,Roxana Tajerian,Somayeh Ebrahimi-Barough,Mahmoud Azami,Shiva Irani,Saranaz Jangjoo,Sadegh Shirian,Jafar Ai +8 more
TL;DR: It has been shown that the freeze-dried PLGA/HA nanocomposite scaffolds can appropriately support the attachment and proliferation of the differentiated osteoblast cells and are a suitable candidate for bone tissue engineering.
References
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