Bone regenerative medicine: classic options, novel strategies, and future directions
TLDR
Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects and may open new insights in the near future.Abstract:
This review analyzes the literature of bone grafts and introduces tissue engineering as a strategy in this field of orthopedic surgery. We evaluated articles concerning bone grafts; analyzed characteristics, advantages, and limitations of the grafts; and provided explanations about bone-tissue engineering technologies. Many bone grafting materials are available to enhance bone healing and regeneration, from bone autografts to graft substitutes; they can be used alone or in combination. Autografts are the gold standard for this purpose, since they provide osteogenic cells, osteoinductive growth factors, and an osteoconductive scaffold, all essential for new bone growth. Autografts carry the limitations of morbidity at the harvesting site and limited availability. Allografts and xenografts carry the risk of disease transmission and rejection. Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects. The combined use of scaffolds, healing promoting factors, together with gene therapy, and, more recently, three-dimensional printing of tissue-engineered constructs may open new insights in the near future.read more
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Patent
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Effects of bone tissue engineering triad components on vascularization process: comparative gene expression and histological evaluation in an ectopic bone-forming model
Jelena G. Najdanović,Vladimir J. Cvetković,Sanja Stojanović,Marija Đ. Vukelić-Nikolić,Maja Cakic-Milosevic,Jelena M. Živković,Stevo Najman +6 more
TL;DR: Adding ASCs combined with PRP to BMM improved the vascularization process in the ectopic bone-forming model, which makes this BTE composition the most favourable among the examined types of implants for application in BTE.
Collagen–Bioceramic Smart Composites
Iulian Vasile Antoniac,Madalina Georgiana Albu,Aurora Antoniac,Laura Cristina Rusu,Mihaela Violeta Ghica +4 more
TL;DR: Different practical aspects related to the processing and characterization of some collagen-based composites that mimic bone tissue are revealed and some characteristics that proved their properties and smart composite– drug delivery systems of the collagen–bioceramic-type composites are discussed.
Journal ArticleDOI
Decellularized Bovine Bone Graft for Zygomatic Bone Reconstruction
Lia Karalashvili,Chichua N,Menabde G,Atskvereli L,Grdzelidze T,Machavariani A,Zurmukhtashvili M,Gogilashvili K,Zurab Kakabadze,Chichua Z +9 more
TL;DR: For the large maxillofacial bone reconstruction procedures, the decellularized bovine bone graft has proven to be effective, easy to handle and biocompatible, providing excellent final aesthetic and functional results.
References
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