Bone regenerative medicine: classic options, novel strategies, and future directions
TLDR
Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects and may open new insights in the near future.Abstract:
This review analyzes the literature of bone grafts and introduces tissue engineering as a strategy in this field of orthopedic surgery. We evaluated articles concerning bone grafts; analyzed characteristics, advantages, and limitations of the grafts; and provided explanations about bone-tissue engineering technologies. Many bone grafting materials are available to enhance bone healing and regeneration, from bone autografts to graft substitutes; they can be used alone or in combination. Autografts are the gold standard for this purpose, since they provide osteogenic cells, osteoinductive growth factors, and an osteoconductive scaffold, all essential for new bone growth. Autografts carry the limitations of morbidity at the harvesting site and limited availability. Allografts and xenografts carry the risk of disease transmission and rejection. Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects. The combined use of scaffolds, healing promoting factors, together with gene therapy, and, more recently, three-dimensional printing of tissue-engineered constructs may open new insights in the near future.read more
Citations
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Evaluation of ‘surgery-friendly’ bone scaffold characteristics: 3D printed ductile BG/PCL scaffold with high inorganic content to repair critical bone defects
TL;DR: Wang et al. as discussed by the authors used the solvent method to add high concentration (wt% 70%) bioglass (BG) into polycaprolactone (PCL), and polyethylene glycol was used as plasticizer to prepare 70% BG/PCL composite scaffolds with high ductility using 3D printing technology.
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An overview of translational research in bone graft biomaterials
TL;DR: This narrative review presents an overview of the translational research on various engineered biomaterials towards bringing transformative changes in orthopedic healthcare and discusses about the emerging trends and future perspectives the next generation bone graft biommaterials.
Evaluation of Amnion-derived Multipotent Progenitor (AMP) Cells and Amnion-derived Cellular Cytokine Solution (ST266) in Promoting Craniomaxillofacial Regenerative Bone Healing in Critical Size Calvarial Defects
Book ChapterDOI
Bone tissue engineering
TL;DR: Bone is a rigid, highly vascularized connective tissue that forms our skeleton as mentioned in this paper , which is a dynamic composite material that is constantly being resorbed, redeposited, and remodeled to accommodate the mechanical and biological demands on the body.
Journal ArticleDOI
Advances in 3D Organoid Models for Stem Cell-Based Cardiac Regeneration
TL;DR: In this article , the authors discuss the clinical implementation and limitations of stem cell-based technologies and ongoing clinical trials and address the advent of 3D culture systems to produce cardiac organoids that may better represent the human heart microenvironment for disease modeling and genetic screening.
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