Bone regenerative medicine: classic options, novel strategies, and future directions
TLDR
Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects and may open new insights in the near future.Abstract:
This review analyzes the literature of bone grafts and introduces tissue engineering as a strategy in this field of orthopedic surgery. We evaluated articles concerning bone grafts; analyzed characteristics, advantages, and limitations of the grafts; and provided explanations about bone-tissue engineering technologies. Many bone grafting materials are available to enhance bone healing and regeneration, from bone autografts to graft substitutes; they can be used alone or in combination. Autografts are the gold standard for this purpose, since they provide osteogenic cells, osteoinductive growth factors, and an osteoconductive scaffold, all essential for new bone growth. Autografts carry the limitations of morbidity at the harvesting site and limited availability. Allografts and xenografts carry the risk of disease transmission and rejection. Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects. The combined use of scaffolds, healing promoting factors, together with gene therapy, and, more recently, three-dimensional printing of tissue-engineered constructs may open new insights in the near future.read more
Citations
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Journal ArticleDOI
Histopathological and biomechanical evaluation of bone healing properties of DBM and DBM-G90 in a rabbit model
TL;DR: Based on the histopathological and biomechanical findings, the DBM and DBM-G90 groups demonstrated superior osteogenic potential; however, G90 shows no superiority over DBM on bone healing.
Book ChapterDOI
Regenerative Repair of Bone Defects with Osteoinductive Hydroxyapatite Fabricated to Match the Defect and Implanted with CAD, CAM, and Computer-Assisted Surgery Systems
TL;DR: A precise repair of a bone defect using computer-aided procedures to demonstrate potential novel technology for efficacious and accurate repair of large bone defects without bone grafting is demonstrated.
Book ChapterDOI
Assessing the potential of mesenchymal stem cells in craniofacial bone repair and regeneration
TL;DR: Rapid bone healing is often the goal for bone healing in craniofacial tissues, and this is ideally achieved by primary bone healing involving predominantly intramembranous ossification where revascularised and bone synthesis facilitate the repair process.
Journal ArticleDOI
Study of bone repair mediated by recombination BMP-2/ recombination CXC chemokine Ligand-13-loaded hollow hydroxyapatite microspheres/chitosan composite.
Jian-Hua Zeng,Shi-Lang Xiong,Linghua Ding,Jianguo Zhou,Jingtang Li,Peng Qiu,Liao Xingen,Long Xiong,Zhisheng Long,Shi-Wei Liu +9 more
TL;DR: The results indicated that the hollow HA microspheres/CS composite could be effective as a delivery vehicle for rhBMP-2 and rhCXCL13 in bone regeneration and bone repair.
Journal ArticleDOI
Preparation and Characterization of Akermanite/Merwinite Scaffolds for Bone Tissue Repair
TL;DR: In this paper, the structural behavior of the synthesized ceramics was examined by means of X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM).
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