Bone regenerative medicine: classic options, novel strategies, and future directions
TLDR
Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects and may open new insights in the near future.Abstract:
This review analyzes the literature of bone grafts and introduces tissue engineering as a strategy in this field of orthopedic surgery. We evaluated articles concerning bone grafts; analyzed characteristics, advantages, and limitations of the grafts; and provided explanations about bone-tissue engineering technologies. Many bone grafting materials are available to enhance bone healing and regeneration, from bone autografts to graft substitutes; they can be used alone or in combination. Autografts are the gold standard for this purpose, since they provide osteogenic cells, osteoinductive growth factors, and an osteoconductive scaffold, all essential for new bone growth. Autografts carry the limitations of morbidity at the harvesting site and limited availability. Allografts and xenografts carry the risk of disease transmission and rejection. Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects. The combined use of scaffolds, healing promoting factors, together with gene therapy, and, more recently, three-dimensional printing of tissue-engineered constructs may open new insights in the near future.read more
Citations
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New bioactive bone-like microspheres with intrinsic magnetic properties obtained by bio-inspired mineralisation process
TL;DR: Thorough investigation of the physicochemical, morphological and biological properties of the new hybrid microspheres, as induced by the presence of the inorganic nanophase and controlled iron substitution into hydroxyapatite lattice, revealed bone-like composition, good cytocompatibility, designed shape and size, and tailored magnetization.
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Structural and Biological Analysis of Mesoporous Lanthanum Doped βTCP For Potential Use as Bone Graft Material
TL;DR: In this paper, mesoporous particles of β-tricalcium phosphate (βTCP, βCa3(PO4)2) and lanthanum (La) doped βTCP were synthesized using wet precipitation method attached with microwave refluxing system.
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Spongostan™ Leads to Increased Regeneration of a Rat Calvarial Critical Size Defect Compared to NanoBone® and Actifuse.
Dirk Wähnert,Julian Koettnitz,Madlen Merten,Daniel Kronenberg,Richard Stange,Johannes F. W. Greiner,Christian Kaltschmidt,Thomas Vordemvenne,Barbara Kaltschmidt +8 more
TL;DR: In this article, the authors compared the clinically applied organic bone substitute materials NanoBone® (nanocrystalline hydroxyapatite and nanostructured silica gel; n = 5) and Actifuse (calcium phosphate with silicate substitution; n= 5) with natural collagen-based Spongostan™ (hardened pork gelatin containing formalin and lauryl alcohol), in bilateral rat critical-size defects (5 mm diameter).
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Application of bovine bone versus bovine DBM graft on bone healing of radial defect in rat
TL;DR: It was showed that there was no difference in the radiological and biomechanical performances of the healing bones between the bovine DBM and bovines bone graft.
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Criteria, Challenges, and Opportunities for Acellularized Allogeneic/Xenogeneic Bone Grafts in Bone Repairing.
Majid Sharifi,Rasoul Kheradmandi,Majid Salehi,Morteza Alizadeh,Timo L.M. ten Hagen,Mojtaba Falahati +5 more
TL;DR: The differences between ABGs created by various techniques and methods applied to them are described to provide a comprehensive understanding of ABG behavior and could provide a better way to combine the treatment approaches needed to treat bone defects.
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