Bone regenerative medicine: classic options, novel strategies, and future directions
TLDR
Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects and may open new insights in the near future.Abstract:
This review analyzes the literature of bone grafts and introduces tissue engineering as a strategy in this field of orthopedic surgery. We evaluated articles concerning bone grafts; analyzed characteristics, advantages, and limitations of the grafts; and provided explanations about bone-tissue engineering technologies. Many bone grafting materials are available to enhance bone healing and regeneration, from bone autografts to graft substitutes; they can be used alone or in combination. Autografts are the gold standard for this purpose, since they provide osteogenic cells, osteoinductive growth factors, and an osteoconductive scaffold, all essential for new bone growth. Autografts carry the limitations of morbidity at the harvesting site and limited availability. Allografts and xenografts carry the risk of disease transmission and rejection. Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects. The combined use of scaffolds, healing promoting factors, together with gene therapy, and, more recently, three-dimensional printing of tissue-engineered constructs may open new insights in the near future.read more
Citations
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Effectiveness of tissue engineered three-dimensional bioactive graft on bone healing and regeneration: an in vivo study with significant clinical value
Mostafa Shahrezaie,Ali Moshiri,Babak Shekarchi,Ahmad Oryan,Nicola Maffulli,Nicola Maffulli,Javad Parvizi +6 more
TL;DR: An approach for promoting bone healing that attempts to overcome prior shortcomings and bioactive grafts may be a suitable option for bone reconstruction, healing and repair is described.
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Vibrational spectroscopy and imaging: applications for tissue engineering.
TL;DR: This review discusses the contributions of vibrational spectroscopic assessment for evaluation of tissue engineered construct composition, both during development and post-implantation, and examines the contribution that vibration spectroscopy via fiber optics and imaging have to tissue engineering approaches.
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Bone remodeling effect of a chitosan and calcium phosphate-based composite.
Lilja Kjalarsdóttir,Arna Dýrfjörd,Atli Dagbjartsson,Elín H Laxdal,Gissur Örlygsson,Johannes Gislason,Jon M. Einarsson,Chuen-How Ng,Halldór Jónsson +8 more
TL;DR: The results suggest that chitosan polymers with %DDA between 50 and 70% enhance the natural bone remodeling mechanism.
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Effects of photobiomodulation on bone defects grafted with bone substitutes: A systematic review of in-vivo animal studies.
TL;DR: In vivo animal studies with a standardized protocol to elucidate the effects of PBMT on biomaterials are required initially prior to clinical studies.
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DLP fabricating of precision GelMA/HAp porous composite scaffold for bone tissue engineering application
Ping Song,Mingxin Li,Boqing Zhang,Xingyu Gui,Yanlong Han,Li Wang,Wenzheng Zhou,Likun Guo,Zhengyu Zhang,Zhengyong Li,Chang-Ge Zhou,Yujiang Fan,Xingdong Zhang +12 more
TL;DR: Wang et al. as discussed by the authors used gelatin methacrylamide (GelMA)/hydroxyapatite (HAp) composite inks to fabricate high-precision scaffolds by DLP printing for bone repair.
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