Bone regenerative medicine: classic options, novel strategies, and future directions
TLDR
Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects and may open new insights in the near future.Abstract:
This review analyzes the literature of bone grafts and introduces tissue engineering as a strategy in this field of orthopedic surgery. We evaluated articles concerning bone grafts; analyzed characteristics, advantages, and limitations of the grafts; and provided explanations about bone-tissue engineering technologies. Many bone grafting materials are available to enhance bone healing and regeneration, from bone autografts to graft substitutes; they can be used alone or in combination. Autografts are the gold standard for this purpose, since they provide osteogenic cells, osteoinductive growth factors, and an osteoconductive scaffold, all essential for new bone growth. Autografts carry the limitations of morbidity at the harvesting site and limited availability. Allografts and xenografts carry the risk of disease transmission and rejection. Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects. The combined use of scaffolds, healing promoting factors, together with gene therapy, and, more recently, three-dimensional printing of tissue-engineered constructs may open new insights in the near future.read more
Citations
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Autologous micrografts from the palatal mucosa for bone regeneration in calvarial defects in rats: a radiological and histological analysis
TL;DR: In this article, the effects of dissociated soft-tissue suspensions relevant to bone regeneration in animal model were evaluated using 12-week-old male Wistar rats, and the new bone formation was evaluated at 1 and 2 weeks after surgery (n = 16).
Journal ArticleDOI
Effect of S53P4 bioactive glass content on structural and in-vitro behavior of hydroxyapatite/bioactive glass mixtures prepared by mechanical milling
P.A. Forero-Sosa,Jose Salazar-Martínez,V.J. Barajas-Aguilar,Israel Olvera-Alvarez,John Henao,D.G. Espinosa-Arbeláez,Gerardo Trápaga-Martínez,A. L. Giraldo-Betancur +7 more
TL;DR: In this paper , the authors presented silicon-substituted hydroxyapatite preparation through planetary ball milling using BHAp and different wt% of S53P4 bioactive glass (5, 10, 15, and 20 wt%) sources.
Posted ContentDOI
Effect of hydroxyapatite microspheres, amoxicillin-hydroxyapatite and collagen-hydroxyapatite composites on human dental pulp-derived mesenchymal stem cells
Yasmine Mendes Pupo,Lidiane Maria Boldrini Leite,Alexandra Cristina Senegaglia,Lisiane Antunes,Jessica Mendes Nadal,Eliane Leal de Lara,Rafael Eiji Saito,Sandra Regina Masetto Antunes,Paulo Vitor Farago +8 more
TL;DR: In general, Col-HAp scaffold showed better features for these dynamic parameters of cell viability and cell migration capacities for hDPSCs, leading to suitable adhesion, proliferation, and differentiation of this osteogenic lineage.
Patent
Devices for creating non-thermal plasma and ozone
TL;DR: In this paper, a plurality of non-thermal plasma emitters are disposed on a rigid or flexible substrate, which enables the device to conform to any surface topography at the time of treatment.
Journal ArticleDOI
The healing of bone defects by cell-free and stem cell-seeded 3D-printed PLA tissue-engineered scaffolds
TL;DR: In this paper , the in-vivo healing of critical-sized bony defects by cell-free and stem cell-seeded 3D-printed PLA scaffolds was studied in rat calvaria bone.
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