Bone regenerative medicine: classic options, novel strategies, and future directions
TLDR
Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects and may open new insights in the near future.Abstract:
This review analyzes the literature of bone grafts and introduces tissue engineering as a strategy in this field of orthopedic surgery. We evaluated articles concerning bone grafts; analyzed characteristics, advantages, and limitations of the grafts; and provided explanations about bone-tissue engineering technologies. Many bone grafting materials are available to enhance bone healing and regeneration, from bone autografts to graft substitutes; they can be used alone or in combination. Autografts are the gold standard for this purpose, since they provide osteogenic cells, osteoinductive growth factors, and an osteoconductive scaffold, all essential for new bone growth. Autografts carry the limitations of morbidity at the harvesting site and limited availability. Allografts and xenografts carry the risk of disease transmission and rejection. Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects. The combined use of scaffolds, healing promoting factors, together with gene therapy, and, more recently, three-dimensional printing of tissue-engineered constructs may open new insights in the near future.read more
Citations
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Long-term biological performance of injectable and degradable calcium phosphate cement
Eline-Claire Grosfeld,Jan Willem M. Hoekstra,Ralf-Peter Herber,Dietmar J.O. Ulrich,John A. Jansen,Jeroen J.J.P. van den Beucken +5 more
TL;DR: It is shown that CPC-PLGA induces favorable bone responses with 90% degradation and 40% new bone formation after an implantation period of 26 weeks, which is similar to that of Bio-Oss®.
Journal ArticleDOI
Nanomaterials for bone tissue regeneration: updates and future perspectives.
Michael J. Hill,Baowen Qi,Rasoul Bayaniahangar,Vida Araban,Zahra Bakhtiary,Michael R. Doschak,Brian C. Goh,Mohammadreza Shokouhimehr,Hojatollah Vali,John F. Presley,Amir A. Zadpoor,Mitchel B. Harris,Parisa Pour Shahid Saeed Abadi,Morteza Mahmoudi +13 more
TL;DR: The focus of this review is to present the recent progress made in the rationale and design of nanomaterials for tissue engineering and drug delivery relevant to bone regeneration.
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Bioactive chitosan biguanidine-based injectable hydrogels as a novel BMP-2 and VEGF carrier for osteogenesis of dental pulp stem cells.
Baharak Divband,Baharak Divband,Marziyeh Aghazadeh,Zahraa Haleem Al-qaim,Mohammad Samiei,Falah H. Hussein,Alireza Shaabani,Shahriar Shahi,Roya Sedghi +8 more
TL;DR: In this paper, a novel in-situ formed injectable hydrogels based on chitosan biguanidine and carboxymethylcellulose loaded with vascular endothelial growth factor (VEGF) and recombinant Bone morphogenetic protein 2 (BMP-2) and studied its influence on osteoblastic differentiation of dental pulp stem cells (DPSCs).
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Ovariectomized Rats with Established Osteopenia have Diminished Mesenchymal Stem Cells in the Bone Marrow and Impaired Homing, Osteoinduction and Bone Regeneration at the Fracture Site
Deepshikha Tewari,Mohd Parvez Khan,Nitin Sagar,Shyamsundar Pal China,Atul Kumar Singh,Subhash Chand Kheruka,Sukanta Barai,Mahesh Chandra Tewari,Geet Kumar Nagar,Achchhe Lal Vishwakarma,Omeje Edwin Ogechukwu,Jayesh R. Bellare,Sanjay Gambhir,Naibedya Chattopadhyay +13 more
TL;DR: Ovx is associated with diminished BM-MSC number and its growth, and Ovx MSC displays impaired engraftment to fracture and osteoinduction besides disordered bone regeneration, in conclusion.
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3D Bioprinting for Musculoskeletal Applications
TL;DR: This review focuses on developments in the field of bioprinting for musculoskeletal tissue engineering, along with discussion on the various approaches for bone, cartilage and connective tissue fabrication.
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