Bone regenerative medicine: classic options, novel strategies, and future directions
TLDR
Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects and may open new insights in the near future.Abstract:
This review analyzes the literature of bone grafts and introduces tissue engineering as a strategy in this field of orthopedic surgery. We evaluated articles concerning bone grafts; analyzed characteristics, advantages, and limitations of the grafts; and provided explanations about bone-tissue engineering technologies. Many bone grafting materials are available to enhance bone healing and regeneration, from bone autografts to graft substitutes; they can be used alone or in combination. Autografts are the gold standard for this purpose, since they provide osteogenic cells, osteoinductive growth factors, and an osteoconductive scaffold, all essential for new bone growth. Autografts carry the limitations of morbidity at the harvesting site and limited availability. Allografts and xenografts carry the risk of disease transmission and rejection. Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects. The combined use of scaffolds, healing promoting factors, together with gene therapy, and, more recently, three-dimensional printing of tissue-engineered constructs may open new insights in the near future.read more
Citations
More filters
Journal ArticleDOI
Multiple drilling and multiple matchstick-like bone allografts for large osteonecrotic lesions in the femoral head: an average 3-year follow-up study
Jun-Ki Moon,Jae Youn Yoon,Chul-Ho Kim,Sun Hyung Lee,Aditya L. Kekatpure,Jun Seong Lee,Pil Whan Yoon +6 more
TL;DR: Multiple drilling and multiple matchstick-like bone allograft may be a useful treatment option for alleviating the symptoms in ONFH patients with large lesions who want to preserve their hips.
Bone Regeneration and Repair: Current and Future Aspects
TL;DR: It is hoped that many bone disease processes secondary to trauma, bone resection due to ablative surgery, ageing, and metabolic or genetic skeletal disorders will be successfully treated with novel bone-regeneration protocols that may address both local and systemic enhancement to optimize outcome.
Journal ArticleDOI
Favorable osteogenic activity of iron doped in silicocarnotite bioceramic: In vitro and in vivo Studies
Jingwei Zhang,Fanyan Deng,Xiao-Liang Liu,Yuwei Ge,Yiming Zeng,Zanjing Zhai,Congqin Ning,Huiwu Li +7 more
TL;DR: In this article , the authors used Fe2O3 to improve the osteogenic ability of a CPS bioceramics by promoting the expression of osteogenic-related genes and proteins.
Book ChapterDOI
Hydroxyapatite Scaffolds Produced from Cuttlefish Bone via Hydrothermal Transformation for Application in Tissue Engineering and Drug Delivery Systems
TL;DR: The optimization of the fabrication technique is required to unravel the endless potential of biomaterials, shedding light on this promising interdisciplinary field, which includes both tissue engineering and drug delivery system approaches.
Journal ArticleDOI
Caracterización del Bloque β-TCP de Sustitución Ósea para la reconstrucción Maxilofacial
TL;DR: The β-TCP block can be used in bone reconstruction but the presence of reduced macropore and micropore sizes could limit efficiency in the substitution and bone regeneration phas .
References
More filters
Journal ArticleDOI
Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures
Dennis M. Black,Steven R. Cummings,David B. Karpf,Jane A. Cauley,Desmond E. Thompson,Michael C. Nevitt,Douglas C. Bauer,Harry K. Genant,William L. Haskell,Robert Marcus,Susan M. Ott,James C. Torner,Sara A. Quandt,Theodore F. Reiss,Kristine E. Ensrud +14 more
TL;DR: Among women with low bone mass and existing vertebral fractures, alendronate is well tolerated and substantially reduces the frequency of morphometric and clinical vertebra fractures, as well as other clinical fractures.
Journal ArticleDOI
Porous scaffold design for tissue engineering
TL;DR: The integration of CTD with SFF to build designer tissue-engineering scaffolds is reviewed and the mechanical properties and tissue regeneration achieved using designer scaffolds are details.
Journal ArticleDOI
Crystal Structure and Hydrogen-Bonding System in Cellulose Iβ from Synchrotron X-ray and Neutron Fiber Diffraction
TL;DR: In this article, the crystal and molecular structure of cellulose Iβ were determined using synchrotron and neutron diffraction data recorded from oriented fibrous samples prepared by aligning cellulose microcrystals from tunicin.
Journal ArticleDOI
Recent advances on chitosan-based micro- and nanoparticles in drug delivery.
TL;DR: The present review outlines the major new findings on the pharmaceutical applications of chitosan-based micro/nanoparticulate drug delivery systems published over the past decade and discusses critically the usefulness of these systems in delivering the bioactive molecules.
Journal ArticleDOI
Biomedical applications of collagen
TL;DR: In this paper, the authors reviewed biomedical applications of collagen including the collagen film, which was developed as a matrix system for evaluation of tissue calcification and for the embedding of a single cell suspension for tumorigenic study.