Bone regenerative medicine: classic options, novel strategies, and future directions
TLDR
Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects and may open new insights in the near future.Abstract:
This review analyzes the literature of bone grafts and introduces tissue engineering as a strategy in this field of orthopedic surgery. We evaluated articles concerning bone grafts; analyzed characteristics, advantages, and limitations of the grafts; and provided explanations about bone-tissue engineering technologies. Many bone grafting materials are available to enhance bone healing and regeneration, from bone autografts to graft substitutes; they can be used alone or in combination. Autografts are the gold standard for this purpose, since they provide osteogenic cells, osteoinductive growth factors, and an osteoconductive scaffold, all essential for new bone growth. Autografts carry the limitations of morbidity at the harvesting site and limited availability. Allografts and xenografts carry the risk of disease transmission and rejection. Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects. The combined use of scaffolds, healing promoting factors, together with gene therapy, and, more recently, three-dimensional printing of tissue-engineered constructs may open new insights in the near future.read more
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Burn wound healing: present concepts, treatment strategies and future directions
TL;DR: The authors discuss the most important events regarding burn wound healing and review the latest treatment strategies that have been used for burn wounds from in vitro to clinical levels, and discusses the role of tissue engineering and regenerative medicine in the future of burn wounds healing, modelling and remodelling.
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Natural origin hydroxyapatite scaffold as potential bone tissue engineering substitute
TL;DR: In vitro and in vivo studies suggest these nontoxic HAp scaffolds graft with osteoconductive support, facilitating new cell growth on the developed scaffold surface have a great potential for application as traumatized tissue augmentation substitute, and ideal for load-bearing bone applications.
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Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications-A Review.
TL;DR: This article sums up the major applications of some biodegradable natural and synthetic polymer scaffolds modified with proteins and peptides, which have been developed within the past five years.
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Potential mechanisms and applications of statins on osteogenesis: Current modalities, conflicts and future directions
TL;DR: The most important issues regarding statins have been reviewed to find out how statins may be beneficial and statin therapy can be improved for treating osteoporosis and fracture injuries.
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Hydroxyapatite-calcium sulfate-hyaluronic acid composite encapsulated with collagenase as bone substitute for alveolar bone regeneration.
Sadhasivam Subramaniam,Yen-Hsin Fang,Savitha Sivasubramanian,Feng-Huei Lin,Feng-Huei Lin,Chun-Pin Lin +5 more
TL;DR: The findings demonstrated that the collagenase inclusion in HAP/CS/HA composite is a feasible approach for the alveolar bone regeneration and the same design can also be applied to other defective tissues.
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