Bone regenerative medicine: classic options, novel strategies, and future directions
TLDR
Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects and may open new insights in the near future.Abstract:
This review analyzes the literature of bone grafts and introduces tissue engineering as a strategy in this field of orthopedic surgery. We evaluated articles concerning bone grafts; analyzed characteristics, advantages, and limitations of the grafts; and provided explanations about bone-tissue engineering technologies. Many bone grafting materials are available to enhance bone healing and regeneration, from bone autografts to graft substitutes; they can be used alone or in combination. Autografts are the gold standard for this purpose, since they provide osteogenic cells, osteoinductive growth factors, and an osteoconductive scaffold, all essential for new bone growth. Autografts carry the limitations of morbidity at the harvesting site and limited availability. Allografts and xenografts carry the risk of disease transmission and rejection. Tissue engineering is a new and developing option that had been introduced to reduce limitations of bone grafts and improve the healing processes of the bone fractures and defects. The combined use of scaffolds, healing promoting factors, together with gene therapy, and, more recently, three-dimensional printing of tissue-engineered constructs may open new insights in the near future.read more
Citations
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Binary bioactive glass composite scaffolds for bone tissue engineering-Structure and mechanical properties in micro and nano scale. A preliminary study
M.J. Woźniak,Adrian Chlanda,Przemysław Oberbek,Marcin Heljak,Katarzyna Czarnecka,Mateusz Janeta,Łukasz John +6 more
TL;DR: The findings show that polymer coated scaffolds had higher average roughness and lower stiffness in comparison to pure bioactive glass scaffolds, suggesting that coating-dependent scaffold properties may promote different cells-scaffold interaction.
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Efficiency of coculture with angiogenic cells or physiological BMP-2 administration on improving osteogenic differentiation and bone formation of MSCs.
TL;DR: These findings confirm the priority of generating cell-based bone constructs with physiological BMP-2 administration and indicate the potential of using angiogenic cells to develop vascularized constructs.
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Bone Graft Substitutes in Single- or Double-Level Anterior Cervical Discectomy and Fusion: A Systematic Review.
TL;DR: Clinical outcomes were improved postoperatively irrespective of the graft used, although dysphagia was significantly greater in studies using BMP, and allograft alone has the lowest cost with similar fusion rates and clinical outcomes compared to other bone graft substitutes.
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Usage of Bone Replacement Grafts in Periodontics and Oral Implantology and Their Current Levels of Clinical Evidence - A Systematic Assessment
TL;DR: Dental providers should be aware of the limited evidence that qualified for a strong rating supporting the clinical efficacy of these materials for periodontics and oral implantology purposes using the inclusion criteria selected in this study.
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Mesenchymal stem cell cultivation in electrospun scaffolds: mechanistic modeling for tissue engineering
TL;DR: This work reviews the main culture and scaffold factors that affect tissue development in vitro regarding the culture of cells inside 3D matrices, focusing on mesenchymal stem cell culture in electrospun scaffolds.
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