Journal ArticleDOI
Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis
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TLDR
Nonalcoholic steatohepatitis is a major cause of cirrhosis and liver cancer and is associated with visceral adiposity and the metabolic syndrome and is nearly as common as type 2 diabetes.Abstract:
Nonalcoholic steatohepatitis is a major cause of cirrhosis and liver cancer. It is associated with visceral adiposity and the metabolic syndrome and is nearly as common as type 2 diabetes. Metabolic stress, inflammation, and fibrosis are the primary pathogenic mechanisms.read more
Citations
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Journal ArticleDOI
Burden of liver diseases in the world
TL;DR: The global prevalence of viral hepatitis remains high, while drug-induced liver injury continues to increase as a major cause of acute hepatitis.
Journal ArticleDOI
The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017 : a systematic analysis for the Global Burden of Disease Study 2017
Sadaf G. Sepanlou,Saeid Safiri,Catherine Bisignano,Kevin S Ikuta,Shahin Merat,Mehdi Saberifiroozi,Hossein Poustchi,Derrick Tsoi,Danny V. Colombara,Amir Abdoli,Rufus A. Adedoyin,Mohsen Afarideh,Sutapa Agrawal,Sohail Ahmad,Elham Ahmadian,Ehsan Ahmadpour,Tomi Akinyemiju,Chisom Joyqueenet Akunna,Vahid Alipour,Amir Almasi-Hashiani,Abdulaziz M. Almulhim,Rajaa Al-Raddadi,Nelson Alvis-Guzman,Nahla Anber,Colin Angus,Amir Anoushiravani,Jalal Arabloo,Ephrem Mebrahtu Araya,Daniel Asmelash,Bahar Ataeinia,Zerihun Ataro,Maha Atout,Floriane Ausloos,Ashish Awasthi,Alaa Badawi,Maciej Banach,Diana Fernanda Bejarano Ramirez,Akshaya Srikanth Bhagavathula,Neeraj Bhala,Krittika Bhattacharyya,Antonio Biondi,Srinivasa Rao Bolla,Archith Boloor,Antonio Maria Borzì,Zahid A Butt,Luis Camera,Ismael R. Campos-Nonato,Félix Carvalho,Dinh-Toi Chu,Sheng Chia Chung,Paolo Cortesi,Vera Marisa Costa,Benjamin C Cowie,Ahmad Daryani,Barbora de Courten,Gebre Teklemariam Demoz,Rupak Desai,Samath D Dharmaratne,Shirin Djalalinia,Hoa Thi Do,Fariba Dorostkar,Thomas M Drake,Manisha Dubey,Bruce Bartholow Duncan,Andem Effiong,Aziz Eftekhari,Aisha Elsharkawy,Arash Etemadi,Mohammad Farahmand,Farshad Farzadfar,Eduarda Fernandes,Irina Filip,Florian Fischer,Ketema Bizuwork Bizuwork Gebremedhin,Birhanu Geta,Syed Amir Gilani,Paramjit Gill,Reyna Alma Gutirrez,Michael Tamene Haile,Arvin Haj-Mirzaian,Saeed Hamid,Milad Hasankhani,Amir Hasanzadeh,Maryam Hashemian,Hamid Yimam Hassen,Simon I. Hay,Khezar Hayat,Behnam Heidari,Andualem Henok,Chi Linh Hoang,Mihaela Hostiuc,Sorin Hostiuc,Vivian Chia-Rong Hsieh,Ehimario U. Igumbor,Olayinka Stephen Ilesanmi,Seyed Sina Naghibi Irvani,Nader Jafari Balalami,Spencer L. James,Panniyammakal Jeemon,Ravi Prakash Jha,Jost B. Jonas,Jacek Jerzy Jozwiak,Ali Kabir,Amir Kasaeian,Hagazi Gebremedhin Kassaye,Adane Teshome Kefale,Rovshan Khalilov,Muhammad Ali Khan,Ejaz Ahmad Khan,Amir Khater,Yun Jin Kim,Ai Koyanagi,Carlo La Vecchia,Lee Ling Lim,Alan D. Lopez,Stefan Lorkowski,Paulo A. Lotufo,Rafael Lozano,Muhammed Magdy Abd El Razek,Hue Thi Mai,Navid Manafi,Amir Manafi,Mohammad Ali Mansournia,Lorenzo G. Mantovani,Giampiero Mazzaglia,Dhruv Mehta,Walter Mendoza,Ritesh G. Menezes,Melkamu Merid Mengesha,Tuomo J. Meretoja,Tomislav Mestrovic,Bartosz Miazgowski,Ted R. Miller,Erkin M. Mirrakhimov,Prasanna Mithra,Babak Moazen,Masoud Moghadaszadeh,Abdollah Mohammadian-Hafshejani,Shafiu Mohammed,Ali H. Mokdad,Pablo Montero-Zamora,Ghobad Moradi,Mukhammad David Naimzada,Vinod C Nayak,Ionut Negoi,Trang Huyen Nguyen,Richard Ofori-Asenso,In-Hwan Oh,Tinuke O Olagunju,Jagadish Rao Padubidri,Keyvan Pakshir,Adrian Pana,Mona Pathak,Akram Pourshams,Navid Rabiee,Amir Radfar,Alireza Rafiei,Kiana Ramezanzadeh,Saleem Muhammad Rana,Salman Rawaf,David Laith Rawaf,Robert C. Reiner,Leonardo Roever,Robin Room,Gholamreza Roshandel,Saeed Safari,Abdallah M. Samy,Juan Sanabria,Benn Sartorius,Maria Inês Schmidt,Subramanian Senthilkumaran,Masood Ali Shaikh,Mehdi Sharif,Amrollah Sharifi,Mika Shigematsu,Jasvinder A. Singh,Amin Soheili,Hafiz Ansar Rasul Suleria,Berhane Fseha Teklehaimanot,Berhe Etsay Tesfay,Marco Vacante,Amir Vahedian-Azimi,Pascual R. Valdez,Tommi Vasankari,Giang Thu Vu,Yasir Waheed,Kidu Gidey Weldegwergs,A. Werdecker,Ronny Westerman,Dawit Zewdu Wondafrash,Adam Belay Wondmieneh,Yordanos Gizachew Yeshitila,Naohiro Yonemoto,Chuanhua Yu,Zoubida Zaidi,Afshin Zarghi,Shira Zelber-Sagi,Kaleab Alemayehu Zewdie,Zhi Jiang Zhang,Xiu Ju Zhao,Mohsen Naghavi,Reza Malekzadeh +201 more
TL;DR: Mortality, prevalence, and DALY estimates are compared with those expected according to the Socio-demographic Index (SDI) as a proxy for the development status of regions and countries, and a significant increase in age-standardised prevalence rate of decompensated cirrhosis between 1990 and 2017.
Journal ArticleDOI
Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies.
TL;DR: This Review highlights novel concepts related to diagnosis, risk prediction, and treatment of non-alcoholic fatty liver disease that could contribute to the development of a multidisciplinary approach for endocrinologists and hepatologists working together in the management of NAFLD.
Journal ArticleDOI
The intestinal microbiota fuelling metabolic inflammation
TL;DR: The authors describe how metabolic disorders, such as type 2 diabetes and nonalcoholic fatty liver disease, are driven by alterations in the composition of the intestinal microbiota and its metabolites, which translocate from the gut across a disrupted intestinal barrier and contribute to metabolic inflammation.
Journal ArticleDOI
Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis.
Xuelian Xiong,Xuelian Xiong,Henry Kuang,Sahar Ansari,Tongyu Liu,Jianke Gong,Jianke Gong,Shuai Wang,Xu-Yun Zhao,Yewei Ji,Chuan Li,Liang Guo,Linkang Zhou,Zhimin Chen,Paola León-Mimila,Meng Ting Chung,Katsuo Kurabayashi,Judy S. Opp,Francisco Campos-Pérez,Hugo Villamil-Ramírez,Samuel Canizales-Quinteros,Robert H. Lyons,Carey N. Lumeng,Beiyan Zhou,Ling Qi,Adriana Huertas-Vazquez,Aldons J. Lusis,X.Z. Shawn Xu,Siming Li,Yonghao Yu,Jun Z. Li,Jiandie D. Lin +31 more
TL;DR: The emergence of NASH-associated macrophages (NAMs) is uncovered, which is marked by high expression of triggering receptors expressed on myeloid cells 2 (Trem2), as a feature of mouse and human NASH that is linked to disease severity and highly responsive to pharmacological and dietary interventions.
References
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Journal ArticleDOI
Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomes
Zobair M. Younossi,Zobair M. Younossi,Aaron B. Koenig,Dinan Abdelatif,Yousef Fazel,Linda Henry,Mark Wymer,Mark Wymer +7 more
TL;DR: As the global epidemic of obesity fuels metabolic conditions, the clinical and economic burden of NAFLD will become enormous, and random‐effects models were used to provide point estimates of prevalence, incidence, mortality and incidence rate ratios.
Journal ArticleDOI
Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis
Arun J. Sanyal,Naga Chalasani,Kris V. Kowdley,Arthur J. McCullough,Anna Mae Diehl,Nathan M. Bass,Brent A. Neuschwander-Tetri,Joel E. Lavine,James Tonascia,Aynur Unalp,Mark L. Van Natta,Jeanne M. Clark,Elizabeth M. Brunt,David E. Kleiner,Jay H. Hoofnagle,Patricia R. Robuck +15 more
TL;DR: Vitamin E was superior to placebo for the treatment of nonalcoholic steatohepatitis in adults without diabetes, and significant benefits of pioglitazone were observed for some of the secondary outcomes.
Journal ArticleDOI
Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease
Paul Angulo,David E. Kleiner,Sanne Dam-Larsen,Leon A. Adams,Einar Björnsson,Phunchai Charatcharoenwitthaya,Peter R. Mills,Jill C. Keach,Heather D. Lafferty,Alisha C. Stahler,Svanhildur Haflidadottir,Flemming Bendtsen +11 more
TL;DR: In a longitudinal study of patients with NAFLD, fibrosis stage, but no other histologic features of steatohepatitis, were associated independently with long-term overall mortality, liver transplantation, and liver-related events.
Journal ArticleDOI
Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study
Christopher D. Williams,Joel Z. Stengel,Michael I. Asike,Dawn M. Torres,Janet Shaw,Maricela Contreras,Cristy L. Landt,Stephen A. Harrison +7 more
TL;DR: Prevalence of nonalcoholic fatty liver disease and NASH is higher than estimated previously and Hispanics and patients with diabetes are at greatest risk for both NAFLD and NASh.
Journal ArticleDOI
Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up.
Mattias Ekstedt,Hannes Hagström,Patrik Nasr,Mats Fredrikson,Per Stål,Stergios Kechagias,Rolf Hultcrantz +6 more
TL;DR: NAFLD patients have increased risk of death, with a high risk ofdeath from cardiovascular disease and liver‐related disease, and the NAS was not able to predict overall mortality, whereas fibrosis stage predicted both overall and disease‐specific mortality.