Cellular Stress Responses: Cell Survival and Cell Death
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TLDR
The implications of cellular stress responses to human physiology and diseases are manifold and will be discussed in this review in the context of some major world health issues such as diabetes, Parkinson's disease, myocardial infarction, and cancer.Abstract:
Cells can respond to stress in various ways ranging from the activation of survival pathways to the initiation of cell death that eventually eliminates damaged cells. Whether cells mount a protective or destructive stress response depends to a large extent on the nature and duration of the stress as well as the cell type. Also, there is often the interplay between these responses that ultimately determines the fate of the stressed cell. The mechanism by which a cell dies (i.e., apoptosis, necrosis, pyroptosis, or autophagic cell death) depends on various exogenous factors as well as the cell's ability to handle the stress to which it is exposed. The implications of cellular stress responses to human physiology and diseases are manifold and will be discussed in this review in the context of some major world health issues such as diabetes, Parkinson's disease, myocardial infarction, and cancer.read more
Citations
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Activation of Apoptosis Signalling Pathways by Reactive Oxygen Species
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Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
Lorenzo Galluzzi,J M Bravo-San Pedro,Ilio Vitale,Stuart A. Aaronson,John M. Abrams,Dieter Adam,Emad S. Alnemri,Lucia Altucci,David W. Andrews,Margherita Annicchiarico-Petruzzelli,Eric H. Baehrecke,Nicolas G. Bazan,Mathieu J.M. Bertrand,Mathieu J.M. Bertrand,Katiuscia Bianchi,Katiuscia Bianchi,Mikhail V. Blagosklonny,Klas Blomgren,Christoph Borner,Dale E. Bredesen,Dale E. Bredesen,Catherine Brenner,Catherine Brenner,Michelangelo Campanella,Eleonora Candi,Francesco Cecconi,Francis Ka-Ming Chan,Navdeep S. Chandel,Emily H. Cheng,Jerry E. Chipuk,John A. Cidlowski,Aaron Ciechanover,Ted M. Dawson,Valina L. Dawson,V De Laurenzi,R De Maria,Klaus-Michael Debatin,N. Di Daniele,Vishva M. Dixit,Brian David Dynlacht,Wafik S. El-Deiry,Gian Maria Fimia,Richard A. Flavell,Simone Fulda,Carmen Garrido,Marie-Lise Gougeon,Douglas R. Green,Hinrich Gronemeyer,György Hajnóczky,J M Hardwick,Michael O. Hengartner,Hidenori Ichijo,Bertrand Joseph,Philipp J. Jost,Thomas Kaufmann,Oliver Kepp,Daniel J. Klionsky,Richard A. Knight,Richard A. Knight,Sharad Kumar,Sharad Kumar,John J. Lemasters,Beth Levine,Beth Levine,Andreas Linkermann,Stuart A. Lipton,Richard A. Lockshin,Carlos López-Otín,Enrico Lugli,Frank Madeo,Walter Malorni,Jean-Christophe Marine,Seamus J. Martin,J-C Martinou,Jan Paul Medema,Pascal Meier,Sonia Melino,Noboru Mizushima,Ute M. Moll,Cristina Muñoz-Pinedo,Gabriel Núñez,Andrew Oberst,Theocharis Panaretakis,Josef M. Penninger,Marcus E. Peter,Mauro Piacentini,Paolo Pinton,Jochen H. M. Prehn,Hamsa Puthalakath,Gabriel A. Rabinovich,Kodi S. Ravichandran,Rosario Rizzuto,Cecília M. P. Rodrigues,David C. Rubinsztein,Thomas Rudel,Yufang Shi,Hans-Uwe Simon,Brent R. Stockwell,Brent R. Stockwell,Gyorgy Szabadkai,Gyorgy Szabadkai,Stephen W.G. Tait,H. L. Tang,Nektarios Tavernarakis,Nektarios Tavernarakis,Yoshihide Tsujimoto,T Vanden Berghe,T Vanden Berghe,Peter Vandenabeele,Peter Vandenabeele,Andreas Villunger,Erwin F. Wagner,Henning Walczak,Eileen White,W. G. Wood,Junying Yuan,Zahra Zakeri,Boris Zhivotovsky,Boris Zhivotovsky,Gerry Melino,Gerry Melino,Guido Kroemer +121 more
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