Effectiveness of the BNT162b2mRNA COVID-19 vaccine in patients with hematological neoplasms in a nationwide mass vaccination setting
TLDR
In this paper , the authors evaluated the relative effectiveness of the mRNA BNT162b2 vaccine in patients with hematological neoplasms compared with matched controls, and found that vaccinated patients had an increased risk of documented COVID-19 infection by polymerase chain reaction; symptomatic infection; hospitalizations; severe COVID19 disease; and COVID -19-related death.About:
This article is published in Blood.The article was published on 2022-03-10 and is currently open access. It has received 50 citations till now. The article focuses on the topics: Medicine & Internal medicine.read more
Citations
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Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer
Balazs Halmos,Amit Verma +1 more
TL;DR: In this paper , the authors showed the significant impact of COVID-19 infection among patients with a cancer diagnosis, with increased morbidity and mortality with advanced age, co-morbidities, and hematologic malignancies receiving highly immunosuppressive therapies.
Journal ArticleDOI
Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer
Lauren C. Shapiro,Balazs Halmos,Amit Verma,Astha Thakkar,Sean T Campbell,Stefanie K. Forest,Kith Pradhan,Jesus D. Gonzalez-Lugo,Ryann Quinn,Tushar D. Bhagat,Gaurav Choudhary,Margaret McCort,R. Alejandro Sica,Mendel Goldfinger,Swati Goel,Jesus Anampa,David Levitz,Ariel Fromowitz,Akash Pradip Shah,Charlotte Sklow,Gregory Alfieri,Andrew D. Racine,Lucia R. Wolgast,Lee M. Greenberger,Amit Verma,Balazs Halmos +25 more
TL;DR: In this article, the anti-COVID-19 immunity dynamics were assessed in patients with cancer in a prospective clinical trial, and the authors detected the waning of immunity 4-6 months post-vaccination with significant increases in anti-spike IgG titers after booster dosing and 56% of seronegative patients seroconverted post-booster vaccination.
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CD20-Targeted Therapy Ablates <i>De Novo</i> Antibody Response to Vaccination but Spares Preestablished Immunity
TL;DR: In this paper , the authors assessed blocking antibodies, total anti-spike IgG, and spike-specific memory B cells in the peripheral blood of 126 patients with lymphoma and 20 age-matched healthy controls 1 and 4 months after COVID-19 vaccination.
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Breakthrough COVID-19 in vaccinated patients with hematologic malignancies: results from the EPICOVIDEHA survey
Livio Pagano,Jon Salmanton-García,Francesco Marchesi,Ola Blennow,Maria Gomes da Silva,Andreas Glenthøj,Jaap van Doesum,Yavuz M. Bilgin,Alberto Lopez-Garcia,F. Itri,R. Nunes Rodrigues,Barbora Weinbergerova,Francesca Farina,Giulia Dragonetti,Caroline Berg Venemyr,Jens Van Praet,Ozren Jakšić,Toni Valković,Iker Falces-Romero,Sonia Martín Pérez,Moraima Jiménez,J. Dávila-Valls,Martin Schonlein,Emanuele Ammatuna,Stef Meers,Mario Delia,Zlate Stojanoski,Anna Nordlander,Tobias Lahmer,László Imre Pinczés,Caterina Buquicchio,Klára Piukovics,Irati Ormazabal-Vélez,Nicola Stefano Fracchiolla,Michail Samarkos,Gustavo-Adolfo Méndez,Jose Angel Hernandez-Rivas,Ildefonso Espigado,Martin Cernan,Verena Petzer,Sylvain Lamure,Roberta Di Blasi,J. Marques de Almeida,Michelina Dargenio,Monika Biernat,Mariarita Sciumè,Cristina de Ramón,N. D. de Jonge,Josip Batinic,Avinash Aujayeb,Monia Marchetti,Guillemette Fouquet,Noemi Fernandez Escalada,Giovanni Zambrotta,M. Sacchi,Anna Guidetti,Fatih Demirken,Lucia Prezioso,Zdenek Racil,Marcio Nucci,Miloš Mladenović,Raphael Liévin,Michaela Hanakova,S. Grafe,Uluhan Sili,Marina Machado,Chiara Cattaneo,Tatjana Adzic-Vukicevic,Luisa Verga,Jorge Labrador,Laman Rahimli,Matteo Bonanni,Francesco Passamonti,Antonio Pagliuca,Paolo Corradini,Martin Hoenigl,Philipp Koehler,Alessandro Busca,Oliver A. Cornely +78 more
TL;DR: While mortality is significantly lower than in the pre-vaccination era, breakthrough COVID-19 in HM is still associated with considerable mortality.
Journal ArticleDOI
SARS-CoV-2 in immunocompromised individuals
Susan DeWolf,Justin Laracy,Miguel-Angel Perales,Mini Kamboj,Marcel R.M. van den Brink,Santosh Vardhana +5 more
TL;DR: Melms et al. as discussed by the authors presented what is known about distinct states of immunologic vulnerability to SARS-CoV-2 and how this information can be harnessed to improve prevention and treatment strategies for immunologically high-risk populations.
References
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Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.
Fernando P. Polack,Stephen J. Thomas,Nicholas Kitchin,Judith Absalon,Alejandra Gurtman,Stephen Lockhart,John L. Perez,Gonzalo Pérez Marc,Edson D. Moreira,Cristiano Zerbini,Ruth Bailey,Kena A. Swanson,Satrajit Roychoudhury,Kenneth Koury,Ping Li,Warren Kalina,David A. Cooper,Robert W. Frenck,Laura L. Hammitt,Özlem Türeci,Haylene Nell,Axel Schaefer,Serhat Ünal,Dina B. Tresnan,Susan Mather,Philip R. Dormitzer,Ugur Sahin,Kathrin U. Jansen,William C. Gruber +28 more
TL;DR: A two-dose regimen of BNT162b2 conferred 95% protection against Covid-19 in persons 16 years of age or older and safety over a median of 2 months was similar to that of other viral vaccines.
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Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study.
Nicole M. Kuderer,Toni K. Choueiri,Dimpy P. Shah,Yu Shyr,Samuel M. Rubinstein,Donna R. Rivera,Sanjay Shete,Chih-Yuan Hsu,Aakash Desai,Gilberto Lopes,Petros Grivas,Petros Grivas,Corrie A. Painter,Solange Peters,Michael A. Thompson,Ziad Bakouny,Gerald Batist,Tanios Bekaii-Saab,Mehmet Asim Bilen,Nathaniel Bouganim,Mateo Bover Larroya,Daniel Castellano,Salvatore Del Prete,Deborah B. Doroshow,Pamela C Egan,Arielle Elkrief,Dimitrios Farmakiotis,Daniel Blake Flora,Matthew D. Galsky,Michael Glover,Elizabeth A. Griffiths,Anthony P. Gulati,Shilpa Gupta,Navid Hafez,Thorvardur R. Halfdanarson,Jessica Hawley,Emily Hsu,Anup Kasi,Ali Raza Khaki,Ali Raza Khaki,Christopher Lemmon,Colleen Lewis,Barbara Logan,Tyler Masters,Rana R. McKay,Ruben A. Mesa,Alicia K. Morgans,Mary F. Mulcahy,Orestis A. Panagiotou,Prakash Peddi,Nathan A. Pennell,Kerry L. Reynolds,Lane R. Rosen,Rachel P. Rosovsky,Mary Salazar,Andrew Schmidt,Sumit A. Shah,Justin Shaya,John A. Steinharter,Keith Stockerl-Goldstein,Suki Subbiah,Donald C. Vinh,Firas Wehbe,Lisa Weissmann,Julie Tsu Yu Wu,Elizabeth Marie Wulff-Burchfield,Zhuoer Xie,Albert C. Yeh,Albert C. Yeh,Peter Paul Yu,Alice Zhou,Leyre Zubiri,Sanjay Mishra,Gary H. Lyman,Gary H. Lyman,Brian I. Rini,Jeremy L. Warner,Maheen Z. Abidi,Jared D. Acoba,Neeraj Agarwal,Syed A. Ahmad,Archana Ajmera,Jessica K. Altman,Anne H. Angevine,Nilo Azad,Michael H. Bar,Aditya Bardia,Jill S. Barnholtz-Sloan,Briana Barrow,Babar Bashir,Rimma Belenkaya,Stephanie Berg,Eric H. Bernicker,Christine Bestvina,Rohit Bishnoi,Genevieve M. Boland,Mark Bonnen,Gabrielle Bouchard,Daniel W. Bowles,Fiona Busser,Angelo Cabal,Paolo Caimi,Theresa M. Carducci,Carla Casulo,James L. Chen,Jessica M. Clement,David D. Chism,Erin Cook,Catherine Curran,Ahmad Daher,Mark E. Dailey,Saurabh Dahiya,John F. Deeken,George D. Demetri,Sandy DiLullo,Narjust Duma,Rawad Elias,Bryan A. Faller,Leslie A. Fecher,Lawrence E. Feldman,Christopher R. Friese,Paul Fu,Julie Fu,Andy Futreal,Justin F. Gainor,Jorge A. Garcia,David Gill,Erin A. Gillaspie,Antonio Giordano,Grace Glace,Axel Grothey,Shuchi Gulati,Michael J. Gurley,Balazs Halmos,Roy S. Herbst,Dawn L. Hershman,Kent Hoskins,Rohit Jain,Salma K. Jabbour,Alokkumar Jha,Douglas B. Johnson,Monika Joshi,Kaitlin M. Kelleher,Jordan Kharofa,Hina Khan,Jeanna Knoble,Vadim S. Koshkin,Amit Kulkarni,Philip E. Lammers,John C. Leighton,Mark A. Lewis,X. Li,Ang Li,K. M.Steve Lo,Arturo Loaiza-Bonilla,Patricia LoRusso,Clarke A. Low,Maryam B. Lustberg,Daruka Mahadevan,Abdul Hai Mansoor,Michelle Marcum,Merry Jennifer Markham,Catherine Handy Marshall,Sandeep H. Mashru,Sara Matar,Christopher McNair,Shannon K. McWeeney,Janice M. Mehnert,Alvaro G. Menendez,Harry Menon,Marcus Messmer,Ryan Monahan,Sarah Mushtaq,Gayathri Nagaraj,Sarah Nagle,Jarushka Naidoo,John M. Nakayama,Vikram M. Narayan,Heather H. Nelson,Eneida R. Nemecek,Ryan Nguyen,Pier Vitale Nuzzo,Paul E. Oberstein,Adam J. Olszewski,Susie Owenby,Mary M. Pasquinelli,John Philip,Sabitha Prabhakaran,Matthew Puc,Amelie G. Ramirez,Joerg Rathmann,Sanjay G. Revankar,Young Soo Rho,Terence Duane Rhodes,Robert L. Rice,Gregory J. Riely,Jonathan Riess,Cameron Rink,Elizabeth Robilotti,Lori J. Rosenstein,Bertrand Routy,Marc A. Rovito,M. Wasif Saif,Amit Sanyal,Lidia Schapira,Candice Schwartz,Oscar K. Serrano,Mansi R. Shah,Chintan Shah,Grace Shaw,Ardaman Shergill,Geoffrey Shouse,Heloisa P. Soares,Carmen C. Solorzano,Pramod K. Srivastava,Karen Stauffer,Daniel G. Stover,Jamie Stratton,Catherine Stratton,Vivek Subbiah,Rulla M. Tamimi,Nizar M. Tannir,Umit Topaloglu,Eli Van Allen,Susan Van Loon,Karen Vega-Luna,Neeta K. Venepalli,Amit Verma,Praveen Vikas,Sarah Wall,Paul L. Weinstein,Matthias Weiss,Trisha Wise-Draper,William A. Wood,Wenxin Xu,Susan Yackzan,Rosemary Zacks,Tian Zhang,Andrea J. Zimmer,Jack West +239 more
TL;DR: The outcomes of a cohort of patients with cancer and COVID-19 are characterised and potential prognostic factors for mortality and severe illness are identified and race and ethnicity, obesity status, cancer type, type of anticancer therapy, and recent surgery were not associated with mortality.
Journal ArticleDOI
COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study.
Lennard Y W Lee,Jean-Baptiste Cazier,Vasileios Angelis,Roland Arnold,Vartika Bisht,Naomi A. Campton,Julia Chackathayil,Vinton Cheng,Helen Curley,Matthew W. Fittall,Luke Freeman-Mills,Spyridon Gennatas,Anshita Goel,Simon Hartley,D.J. Hughes,David J. Kerr,Alvin J.X. Lee,Rebecca Lee,Sophie McGrath,Christopher P. Middleton,N. Murugaesu,Thomas Newsom-Davis,Alicia Okines,Anna Olsson-Brown,Claire Palles,Yi Pan,Ruth Pettengell,Thomas Powles,Emily A. Protheroe,Karin Purshouse,Archana Sharma-Oates,Shivan Sivakumar,Ashley J. Smith,Thomas Starkey,Chris D. Turnbull,Csilla Várnai,Nadia Yousaf,Rachel Kerr,Gary Middleton +38 more
TL;DR: The clinical and demographic characteristics and COVID-19 outcomes in patients with cancer appear to be principally driven by age, gender, and comorbidities.
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Efficacy of the BNT162b2 mRNA COVID-19 Vaccine in Patients with Chronic Lymphocytic Leukemia.
Yair Herishanu,Irit Avivi,Anat Amit Aharon,Gabi Shefer,Shai Levi,Yotam Bronstein,Miguel Morales,Tomer Ziv,Yamit Shorer Arbel,Lydia Scarfò,Erel Joffe,Chava Perry,Paolo Ghia +12 more
TL;DR: In this article, the authors evaluated humoral immune responses to the BNT162b2 mRNA COVID-19 vaccine in patients with CLL and compared responses with those obtained in age-matched healthy control subjects.
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Safety and immunogenicity of one versus two doses of the COVID-19 vaccine BNT162b2 for patients with cancer: interim analysis of a prospective observational study.
Leticia Monin,Adam Laing,Miguel Muñoz-Ruiz,Duncan R. McKenzie,Irene del Molino del Barrio,Irene del Molino del Barrio,Thanussuyah Alaguthurai,Clara Domingo-Vila,Thomas Hayday,Carl Graham,Jeffrey Seow,Sultan Abdul-Jawad,Shraddha Kamdar,Elizabeth Harvey-Jones,Rosalind Graham,Jack Cooper,Muhammad Shamim Khan,Jennifer Vidler,Helen Kakkassery,Shubhankar Sinha,Richard Davis,Liane Dupont,Isaac Francos Quijorna,Charlotte O'Brien-Gore,Puay Ling Lee,Josephine Eum,Maria Conde Poole,Magdalene Joseph,Daniel Davies,Daniel Davies,Yin Wu,Angela Swampillai,Bernard V. North,Ana Montes,Mark Harries,Anne Rigg,James Spicer,James Spicer,Michael H. Malim,Paul Fields,Paul Fields,Piers E.M. Patten,Piers E.M. Patten,Francesca Di Rosa,Sophie Papa,Sophie Papa,Timothy Tree,Katie J. Doores,Adrian Hayday,Adrian Hayday,Sheeba Irshad,Sheeba Irshad +51 more
TL;DR: In this paper, the safety and immunogenicity of the BNT162b2 (Pfizer-BioNTech) vaccine in patients with cancer was evaluated using data from three London hospitals between Dec 8, 2020 and Feb 18, 2021.