Epigenetic signatures of starting and stopping smoking.
Daniel L. McCartney,Anna J. Stevenson,Robert F. Hillary,Rosie M. Walker,Mairead L. Bermingham,Stewart W. Morris,Toni-Kim Clarke,Archie Campbell,Alison D. Murray,Heather C. Whalley,David J. Porteous,Peter M. Visscher,Andrew M. McIntosh,Kathryn L. Evans,Ian J. Deary,Riccardo E. Marioni +15 more
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TLDR
The findings suggest that smoking–associated DNA methylation changes are a result of prolonged exposure to cigarette smoke, and can be reversed following cessation, and may provide an additional criterion on which to stratify risk.About:
This article is published in EBioMedicine.The article was published on 2018-11-01 and is currently open access. It has received 62 citations till now. The article focuses on the topics: Former Smoker.read more
Citations
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Journal ArticleDOI
A systematic review of smoking-related epigenetic alterations.
TL;DR: This systematic review lists the epigenetic events/alterations known to occur in response to cigarette smoke exposure and identifies the major genes and miRNAs that are potential targets for translational research in associated pathologies.
Journal ArticleDOI
Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene-environment interactions across the lifespan.
TL;DR: In this article , the authors argue that COPD should be viewed as a clinical syndrome characterised by a recognisable pattern of chronic symptoms and structural or functional impairments due to gene-environment interactions across the lifespan that influence normal lung development and ageing.
Journal ArticleDOI
Epigenetic prediction of major depressive disorder
Miruna C. Barbu,Xueyi Shen,Rosie M. Walker,David M. Howard,David M. Howard,Kathryn L. Evans,Heather C. Whalley,David J. Porteous,Stewart W. Morris,Ian J. Deary,Yanni Zeng,Riccardo E. Marioni,Toni-Kim Clarke,Andrew M. McIntosh +13 more
TL;DR: Testing the association of MRS with 61 behavioural phenotypes found that whilst PRS were associated with psychosocial and mental health phenotypes, MRS were more strongly associated with lifestyle and sociodemographic factors.
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Epigenetic mechanisms influencing COVID-19.
TL;DR: In this article, the major epigenetic pathways at play during COVID-19 disease and discusses ongoing clinical trials that will hopefully contribute to slowing the spread of SARS-CoV-2.
Journal ArticleDOI
DNA methylation-based predictors of health: applications and statistical considerations
Paul Yousefi,Matthew Suderman,Ryan Langdon,Oliver Whitehurst,George Davey Smith,Caroline L Relton +5 more
TL;DR: This Review evaluates the progress of existing DNA methylation-based predictors, including the contribution of machine learning techniques, and assesses the uptake of key statistical best practices needed to ensure their reliable performance.
References
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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.
Journal ArticleDOI
Some distance properties of latent root and vector methods used in multivariate analysis
TL;DR: In this paper, the authors derived necessary and sufficient conditions for a solution to exist in real Euclidean space for a multivariate multivariate sample of size n as points P1, P2,..., PI in a Euclidian space and discussed the interpretation of the distance A(Pi, Pj) between the ith and jth members of the sample.
segmented: An R package to Fit Regression Models with Broken-Line Relationships
Abstract: Segmented or broken-line models are regression models where the relationships between the response and one or more explanatory variables are piecewise linear, namely represented by two or more straight lines connected at unknown values: these values are usually referred as breakpoints, changepoints or even joinpoints. Hereafter we use such words indistinctly. Broken-line relationships are common in many fields, including epidemiology, occupational medicine, toxicology, and ecology, where sometimes it is of interest to assess threshold value where the effect of the covariate changes (Ulm, 1991; Betts et al., 2007).
Journal ArticleDOI
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease.
Thorgeir E. Thorgeirsson,Frank Geller,Patrick Sulem,Thorunn Rafnar,Anna Wiste,Anna Wiste,Kristinn P. Magnusson,Andrei Manolescu,Gudmar Thorleifsson,Hreinn Stefansson,Andres Ingason,Simon N. Stacey,Jon Thor Bergthorsson,Steinunn Thorlacius,Julius Gudmundsson,Thorlakur Jonsson,Margret Jakobsdottir,Jona Saemundsdottir,Olof Birna Olafsdottir,Larus J. Gudmundsson,Gyda Bjornsdottir,Kristleifur Kristjansson,Halla Skuladottir,Helgi J Isaksson,Tomas Gudbjartsson,Gregory T. Jones,Thomas Mueller,Anders Gottsäter,Andrea Flex,Katja K.H. Aben,Femmie de Vegt,Peter F.A. Mulders,Dolores Isla,Maria Vidal,Laura Asín,Berta Saez,L. Murillo,Thorsteinn Blondal,Halldor Kolbeinsson,Jón G. Stefánsson,Ingunn Hansdottir,Valgerdur Runarsdottir,Roberto Pola,Bengt Lindblad,Andre M. van Rij,Benjamin Dieplinger,Meinhard Haltmayer,Jose I. Mayordomo,Lambertus A. Kiemeney,Stefan E Matthiasson,Hogni Oskarsson,Thorarinn Tyrfingsson,Daniel F. Gudbjartsson,Jeffrey R. Gulcher,Steinn Jonsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Augustine Kong,Kari Stefansson,Kari Stefansson +59 more
TL;DR: A common variant in the nicotinic acetylcholine receptor gene cluster on chromosome 15q24 with an effect on smoking quantity, ND and the risk of two smoking-related diseases in populations of European descent is identified.
Journal ArticleDOI
A data-driven approach to preprocessing Illumina 450K methylation array data
Ruth Pidsley,Chloe C. Y. Wong,Manuela Volta,Katie Lunnon,Jonathan Mill,Jonathan Mill,Leonard C. Schalkwyk +6 more
TL;DR: It is demonstrated that quantile normalization methods produce marked improvement, even in highly consistent data, by all three metrics, and that careful selection of preprocessing steps can minimize variance and thus improve statistical power, especially for the detection of the small absolute DNA methylation changes likely associated with complex disease phenotypes.
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