Ferritin in the coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis.
Linlin Cheng,Haolong Li,Liubing Li,Chenxi Liu,Songxin Yan,Haizhen Chen,Haizhen Chen,Yongzhe Li +7 more
TLDR
The aim of this study was to determine the role of ferritin in COVID‐19, a pandemic coronavirus disease that has rapidly developed into aPandemic.Citations
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
Journal ArticleDOI
Diverse Functional Autoantibodies in Patients with COVID-19.
Eric Wang,Tianyang Mao,Jon Klein,Yile Dai,John D. Huck,Jillian R. Jaycox,Feimei Liu,Ting Zhou,Benjamin Israelow,Patrick Wong,Andreas Coppi,Carolina Lucas,Julio Silva,Ji Eun Oh,Eric Song,Emily S. Perotti,Neil S Zheng,Suzanne Fischer,Melissa Campbell,John Fournier,Anne L. Wyllie,Chantal B.F. Vogels,Isabel M. Ott,Chaney C. Kalinich,Mary E. Petrone,Anne E. Watkins,Charles S. Dela Cruz,Shelli F. Farhadian,Wade L. Schulz,Shuangge Ma,Nathan D. Grubaugh,Albert I. Ko,Akiko Iwasaki,Akiko Iwasaki,Aaron M. Ring +34 more
TL;DR: In this article, a high-throughput autoantibody discovery technique known as rapid extracellular antigen profiling was used to screen a cohort of 194 individuals infected with SARS-CoV-2, comprising 172 patients with COVID-19 and 22 health care workers with mild disease or asymptomatic infection, for auto-antibodies against 2,770 proteins (members of the exoproteome).
Journal ArticleDOI
The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity.
Marcin F. Osuchowski,Martin Sebastian Winkler,Tomasz Skirecki,Sara Cajander,Manu Shankar-Hari,Manu Shankar-Hari,Gunnar Lachmann,Guillaume Monneret,Fabienne Venet,Michael Bauer,Frank M. Brunkhorst,Sebastian Weis,Alberto García-Salido,Matthijs Kox,Jean-Marc Cavaillon,Florian Uhle,Markus A. Weigand,Stefanie B. Flohé,W. Joost Wiersinga,Raquel Almansa,Amanda de la Fuente,Ignacio Martin-Loeches,Christian Meisel,Thibaud Spinetti,Joerg C. Schefold,Catia Cilloniz,Antoni Torres,Antoni Torres,Evangelos J. Giamarellos-Bourboulis,Ricard Ferrer,Ricard Ferrer,Massimo Girardis,Andrea Cossarizza,Mihai G. Netea,Mihai G. Netea,Mihai G. Netea,Tom van der Poll,Jesus F. Bermejo-Martin,Ignacio Rubio +38 more
TL;DR: The authors reviewed the intricacies of COVID-19 pathophysiology, its various phenotypes, and the anti-SARS-CoV-2 host response at the humoral and cellular levels.
Posted ContentDOI
Diverse Functional Autoantibodies in Patients with COVID-19
Eric Wang,Tianyang Mao,Jon Klein,Yile Dai,John D. Huck,Feimei Liu,Neil S Zheng,Ting Zhou,Benjamin Israelow,Patrick Wong,Carolina Lucas,Julio Silva,Ji Eun Oh,Eric Song,Emily S. Perotti,Suzanne Fischer,Melissa Campbell,John Fournier,Anne L. Wyllie,Chantal B.F. Vogels,Isabel M. Ott,Chaney C. Kalinich,Mary E. Petrone,Anne E. Watkins,Yale Impact Team,Charles S. Dela Cruz,Shelli F. Farhadian,Wade L. Schulz,Nathan D. Grubaugh,Albert I. Ko,Akiko Iwasaki,Akiko Iwasaki,Aaron M. Ring +32 more
TL;DR: It is established that these autoantibodies perturb immune function and impair virological control by inhibiting immunoreceptor signaling and by altering peripheral immune cell composition, and found that murine surrogates of these autoantsibodies exacerbate disease severity in a mouse model of SARS-CoV-2 infection.
Journal ArticleDOI
Association of clinical factors and recent anticancer therapy with COVID-19 severity among patients with cancer: a report from the COVID-19 and Cancer Consortium.
Petros Grivas,Ali Raza Khaki,Ali Raza Khaki,Trisha Wise-Draper,Benjamin French,C. Hennessy,Chih-Yuan Hsu,Yu Shyr,X. Li,Toni K. Choueiri,Corrie A. Painter,Solange Peters,Brian I. Rini,Michael A. Thompson,Sanjay Mishra,Donna R. Rivera,Jared D. Acoba,Maheen Z. Abidi,Ziad Bakouny,Babar Bashir,T. S. Bekaii-Saab,Stephanie Berg,Eric H. Bernicker,Mehmet Asim Bilen,P. Bindal,Rohit Bishnoi,Nathaniel Bouganim,Daniel W. Bowles,Angelo Cabal,Paolo Caimi,David D. Chism,J. Crowell,Catherine Curran,Aakash Desai,Barry Dixon,Deborah B. Doroshow,Eric B. Durbin,Arielle Elkrief,Dimitrios Farmakiotis,A. Fazio,Leslie A. Fecher,Daniel Blake Flora,Christopher R. Friese,Julie Fu,Shirish M. Gadgeel,Matthew D. Galsky,David Gill,Michael Glover,Sharad Goyal,Punita Grover,Shuchi Gulati,Shilpa Gupta,Susan Halabi,Thorvardur R. Halfdanarson,Balazs Halmos,D. J. Hausrath,Jessica Hawley,Emily Hsu,Minh-Phuong Huynh-Le,Clara Hwang,Chinmay Jani,A. Jayaraj,Douglas B. Johnson,Anup Kasi,Hina Khan,Vadim S. Koshkin,Nicole M. Kuderer,Daniel Kwon,Philip E. Lammers,Ang Li,Arturo Loaiza-Bonilla,Clarke A. Low,Maryam B. Lustberg,Gary H. Lyman,Rana R. McKay,Christopher McNair,Harry Menon,Ruben A. Mesa,V. Mico,D. Mundt,Gayathri Nagaraj,E. S. Nakasone,John M. Nakayama,A. Nizam,N. L. Nock,Cathleen Park,Jaymin M. Patel,Kripa Patel,Prakash Peddi,Nathan A. Pennell,A. J. Piper-Vallillo,Matthew Puc,Deepak Ravindranathan,M. E. Reeves,D. Y. Reuben,Lori J. Rosenstein,Rachel P. Rosovsky,Samuel M. Rubinstein,M. Salazar,Andrew Schmidt,Gary K. Schwartz,Mansi R. Shah,Sumit A. Shah,Chintan Shah,Justin Shaya,Sunny R K Singh,M. Smits,Keith Stockerl-Goldstein,Daniel G. Stover,M. Streckfuss,Suki Subbiah,L. Tachiki,E. Tadesse,Astha Thakkar,Matthew D Tucker,Amit Verma,Donald C. Vinh,Matthias Weiss,Jia Wu,E. Wulff-Burchfield,Zhuoer Xie,Peter Paul Yu,Tian Zhang,Alice Zhou,Huili Zhu,Leyre Zubiri,Dimpy P. Shah,Jeremy L. Warner,Gd L. Lopes +128 more
TL;DR: In this article, the authors analyzed a cohort of patients with cancer and coronavirus 2019 (COVID-19) reported to the COVID19 and Cancer Consortium (CCC19) to identify prognostic clinical factors, including laboratory measurements and anticancer therapies.
References
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The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
Alessandro Liberati,Douglas G. Altman,Jennifer Tetzlaff,Cynthia D. Mulrow,Peter C Gøtzsche,John P. A. Ioannidis,Mike Clarke,Mike Clarke,Philip J. Devereaux,Jos Kleijnen,David Moher +10 more
TL;DR: An Explanation and Elaboration of the PRISMA Statement is presented and updated guidelines for the reporting of systematic reviews and meta-analyses are presented.
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Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
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A pneumonia outbreak associated with a new coronavirus of probable bat origin
Peng Zhou,Xing-Lou Yang,Xian Guang Wang,Ben Hu,Lei Zhang,Wei Zhang,Hao Rui Si,Yan Zhu,Bei Li,Chao Lin Huang,Hui-Dong Chen,Jing Chen,Yun Luo,Hua Guo,Ren Di Jiang,Meiqin Liu,Ying Chen,Xu Rui Shen,Xi Wang,Xiao Shuang Zheng,Kai Zhao,Quanjiao Chen,Fei Deng,Lin Lin Liu,Bing Yan,Fa Xian Zhan,Yan-Yi Wang,Gengfu Xiao,Zhengli Shi +28 more
TL;DR: Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
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