Genetics of MDS
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TLDR
A review of the recent progress in myelodysplastic syndromes (MDS) genetics can be found in this paper, where a comprehensive registry of driver mutations recurrently found in a recognizable fraction of MDS patients has been revealed.About:
This article is published in Blood.The article was published on 2019-03-07 and is currently open access. It has received 197 citations till now.read more
Citations
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Journal ArticleDOI
Molecular International Prognostic Scoring System for Myelodysplastic Syndromes
TL;DR: In this paper , the authors developed a clinical-molecular prognostic model (IPSS-Molecular [IPSS]-M) for myelodysplastic syndromes (MDS) based on the International Prognostic Scoring System-Revised ( IPSS-R), which considers hematologic parameters and cytogenetic abnormalities.
Journal ArticleDOI
Real-World Validation of Molecular International Prognostic Scoring System for Myelodysplastic Syndromes
Elisabetta Sauta,Marie Robin,Matteo Bersanelli,Erica Travaglino,Manja Meggendorfer,Lin-Pierre Zhao,Juan Carlos Caballero Berrocal,Claudia Sala,Giulia Maggioni,Massimo Bernardi,Carmen Di Grazia,Luca Vago,Giulia Rivoli,Lorenza Borin,S. D'Amico,Cristina Tentori,Marta Ubezio,Alessia Campagna,Antonio Russo,Daniele Mannina,Luca Lanino,Patrizia Chiusolo,Luisa Giaccone,Maria Teresa Voso,Marta Riva,Esther Oliva,Matteo Zampini,Elena Riva,Olivier Nibourel,Marilena Bicchieri,Niccolo Bolli,Alessandro Rambaldi,Francesco Passamonti,Victor Savevski,Armando Santoro,Ulrich Germing,Shahram Kordasti,Valeria Santini,María Díez-Campelo,Guillermo Sanz,Francesc Solé,Wolfgang Kern,Uwe Platzbecker,Lionel Ades,Pierre Fenaux,Torsten Haferlach,Gastone Castellani,Matteo G. Della Porta +47 more
TL;DR: In this article , a new clinical-molecular prognostic model, the Molecular International Prognostic Scoring System (IPSS-M) was proposed to improve the prediction of clinical outcome of the currently available tool (Revised International Probabilistic Score System [IPSS]-R).
Journal ArticleDOI
Natural Killer Cells in Myeloid Malignancies: Immune Surveillance, NK Cell Dysfunction, and Pharmacological Opportunities to Bolster the Endogenous NK Cells.
Mattias Carlsten,Marcus Järås +1 more
TL;DR: This review focuses on mechanisms that are involved in suppressing NK cells in patients with myeloid leukemia and MDS, and means to restore their full anti-tumor potential, and discusses novel molecular targets and approaches to redirect and/or unleash the NK cells against the leukemic cells.
Journal ArticleDOI
Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS
TL;DR: In this article, the role of dysregulated innate immune and inflammatory signaling that contribute to the competitive advantage and clonal dominance of preleukemic and myelodysplastic syndrome (MDS) derived hematopoietic cells is discussed.
Journal ArticleDOI
Genetics of progression from MDS to secondary leukemia
TL;DR: Advances are outlined in the study of MDS to secondary AML progression, with a focus on the genetics of progression, and the advantages of incorporating molecular genetic data in the diagnosis, classification, and monitoring of M DS to secondaryAML progression are discussed.
References
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