GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Gordon H. Guyatt,Andrew D Oxman,Gunn Elisabeth Vist,Regina Kunz,Yngve Falck-Ytter,Pablo Alonso-Coello,Holger J. Schünemann +6 more
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The advantages of the GRADE system are explored, which is increasingly being adopted by organisations worldwide and which is often praised for its high level of consistency.Abstract:
Guidelines are inconsistent in how they rate the quality of evidence and the strength of recommendations. This article explores the advantages of the GRADE system, which is increasingly being adopted by organisations worldwideread more
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Effectiveness of Manual Therapy and Therapeutic Exercise for Temporomandibular Disorders: Systematic Review and Meta-Analysis
Susan Armijo-Olivo,Laurent Pitance,Vandana Singh,Francisco Macedo Neto,Norman M.R. Thie,Ambra Michelotti +5 more
TL;DR: No high-quality evidence was found, indicating that there is great uncertainty about the effectiveness of exercise and MT for treatment of TMD, and the evidence was generally downgraded based on assessments of risk of bias.
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Drugs for relief of pain in patients with sciatica: systematic review and meta-analysis
Rafael Z. Pinto,Christopher G. Maher,Manuela L. Ferreira,Paulo H. Ferreira,Mark J. Hancock,Vinícius Cunha Oliveira,Andrew J. McLachlan,Bart W. Koes +7 more
TL;DR: The efficacy and tolerability of drugs commonly prescribed for the management of sciatica in primary care is unclear and the evidence to judge the efficacy of non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, antidepressants, anticonvulsants, muscle relaxants, and opioid analgesics ranged from moderate to low quality.
Journal ArticleDOI
The difficult airway with recommendations for management – Part 2 – The anticipated difficult airway
J. Adam Law,Natasha Broemling,Richard M. Cooper,Pierre Drolet,Laura V. Duggan,Donald E. G. Griesdale,Orlando Hung,Philip M. Jones,George Kovacs,Simon Massey,Ian R. Morris,Timothy Mullen,Michael F. Murphy,Roanne Preston,Viren N. Naik,Jeanette Scott,Shean Stacey,Timothy P. Turkstra,David T. Wong +18 more
TL;DR: With an appropriate airway evaluation and consideration of relevant contextual issues, a rational decision can be made on whether an awake approach to tracheal intubation will maximize patient safety or if airway management can safely proceed after induction of general anesthesia.
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Fluid Resuscitation in Sepsis: A Systematic Review and Network Meta-analysis
Bram Rochwerg,Waleed Alhazzani,Anees Sindi,Diane Heels-Ansdell,Lehana Thabane,Alison Fox-Robichaud,Lawrence Mbuagbaw,Wojciech Szczeklik,Fayez Alshamsi,Sultan Altayyar,Wang-Chun Ip,Guowei Li,Michael Wang,Anna Włudarczyk,Qi Zhou,Gordon H. Guyatt,Deborah J. Cook,Roman Jaeschke,Djillali Annane,Fluids in Sepsis +19 more
TL;DR: It is reported that resuscitation with an albumin-containing solution in patients with sepsis may decrease mortality compared with solutions containing no albumin, and a recent large pragmatic trial comparing colloids with crystalloids suggested a 90-day mortality benefit with colloids.
Reference EntryDOI
Oral hygiene care for critically ill patients to prevent ventilator associated pneumonia [Intervention Protocol]
Zongdao Shi,Huixu Xie,Ping Wang,Yan Wu,E. Chen,Linda Ng,Helen V Worthington,Mervyn Singer,Ian Needleman +8 more
TL;DR: High quality evidence from 18 RCTs shows that CHX mouthrinse or gel, as part of OHC, reduces the risk of VAP compared to placebo or usual care, which is equivalent to a number needed to treat for an additional beneficial outcome (NNTB) of 17, which indicates that for every 17 ventilated patients in intensive care receiving OHC including chlorhexidine, one outcome of V AP would be prevented.
References
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Jacques E. Rossouw,Garnet L. Anderson,Ross L. Prentice,Andrea Z. LaCroix,Charles Kooperberg,Marcia L. Stefanick,Rebecca D. Jackson,Shirley A.A. Beresford,Barbara V. Howard,Karen C. Johnson,Jane Morley Kotchen,Judith K. Ockene +11 more
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David Atkins,Martin P Eccles,Signe Flottorp,Gordon H. Guyatt,David Henry,Suzanne Hill,Alessandro Liberati,Dianne L. O'Connell,Andrew D Oxman,Bob Phillips,Holger J. Schünemann,Holger J. Schünemann,Tessa Tan-Torres Edejer,Gunn Elisabeth Vist,John W Williams +14 more
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