GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Gordon H. Guyatt,Andrew D Oxman,Gunn Elisabeth Vist,Regina Kunz,Yngve Falck-Ytter,Pablo Alonso-Coello,Holger J. Schünemann +6 more
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The advantages of the GRADE system are explored, which is increasingly being adopted by organisations worldwide and which is often praised for its high level of consistency.Abstract:
Guidelines are inconsistent in how they rate the quality of evidence and the strength of recommendations. This article explores the advantages of the GRADE system, which is increasingly being adopted by organisations worldwideread more
Citations
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Risk factors which predispose first-time traumatic anterior shoulder dislocations to recurrent instability in adults: a systematic review and meta-analysis
TL;DR: Sex, age at initial dislocation, time from initial dislocated, hyperlaxity and greater tuberosity fractures were key risk factors in at least two good quality cohort studies resulting in strong evidence as concluded in the GRADE criteria.
Journal ArticleDOI
Congenital Cytomegalovirus: A European Expert Consensus Statement on Diagnosis and Management.
Suzanne Luck,Jantien W Wieringa,Daniel Blázquez-Gamero,Philipp Henneke,Katharina Schuster,Karina Butler,Maria Grazia Capretti,Maria José Cilleruelo,Nigel Curtis,Francesca Garofoli,Paul T. Heath,Elias Iosifidis,Nigel Klein,Giuseppina Lombardi,Hermione Lyall,Tea Nieminen,Dasja Pajkrt,Vassiliki Papaevangelou,Klara M. Posfay-Barbe,Laura Puhakka,Emmanuel Roilides,Pablo Rojo,Jesús Saavedra-Lozano,Teshri Shah,Mike Sharland,Harri Saxen,Ann C. T. M. Vossen +26 more
TL;DR: Meta-analysis shows that although long-term sequelae, especially SNHL, are more common in those with clinically detectable disease at birth, they are also found in 13% of those without clinical features attributable to CMV on initial examination.
Journal ArticleDOI
Peginterferon alpha-2a is associated with higher sustained virological response than peginterferon alfa-2b in chronic hepatitis C: Systematic review of randomized trials†‡
TL;DR: Current evidence suggests that peginterferon alpha‐2a is associated with higher SVR than peginerferon alfa‐2b, however, the paucity of evidence on adverse events curbs the decision to definitively recommend one pegintersferon over the other, because any potential benefit must outweigh the risk of harm.
Journal ArticleDOI
Guidelines on diagnosis, prognosis, and management of peripheral artery disease in patients with foot ulcers and diabetes (IWGDF 2019 update)
Robert J. Hinchliffe,Rachael O. Forsythe,Jan Apelqvist,Edward J. Boyko,Robert Fitridge,Joon Pio Hong,Konstantinos Katsanos,Joseph L. Mills,Sigrid Nikol,Jim A. Reekers,Maarit Venermo,R. Eugene Zierler,Nicolaas C. Schaper +12 more
TL;DR: The updated 2019 guidelines on diagnosis, prognosis, and management of PAD in patients with a foot ulcer and diabetes are presented, and some key future topics of particular research interest are suggested.
Journal ArticleDOI
Interventions for Old World cutaneous leishmaniasis.
Julio Heras-Mosteiro,Begoña Monge-Maillo,Mariona Pinart,Patricia Lopez Pereira,Ludovic Reveiz,Emely Garcia-Carrasco,Pedro Campuzano Cuadrado,Ana Royuela,Irene Mendez Roman,Rogelio López-Vélez +9 more
TL;DR: The creation of an international platform to improve quality and standardization of future trials in order to inform clinical practice is suggested and a desperate need for large well conducted studies that evaluate long-term effects of current therapies is suggested.
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