GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Gordon H. Guyatt,Andrew D Oxman,Gunn Elisabeth Vist,Regina Kunz,Yngve Falck-Ytter,Pablo Alonso-Coello,Holger J. Schünemann +6 more
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The advantages of the GRADE system are explored, which is increasingly being adopted by organisations worldwide and which is often praised for its high level of consistency.Abstract:
Guidelines are inconsistent in how they rate the quality of evidence and the strength of recommendations. This article explores the advantages of the GRADE system, which is increasingly being adopted by organisations worldwideread more
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Patients' online access to their electronic health records and linked online services: a systematic interpretative review.
Simon de Lusignan,Freda Mold,Aziz Sheikh,Azeem Majeed,Jeremy C Wyatt,Tom Quinn,Mary Cavill,Toto Anne Gronlund,Christina Franco,Umesh Chauhan,Hannah Blakey,Neha Kataria,Fiona Barker,Beverley Ellis,Phil Koczan,Theodoros N. Arvanitis,Mary McCarthy,Simon Jones,Imran Rafi +18 more
TL;DR: Investigating the effect of providing patients online access to their electronic health record (EHR) and linked transactional services on the provision, quality and safety of healthcare found patient online access and services offer increased convenience and satisfaction.
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Risk factors for relapse and recurrence of depression in adults and how they operate: A four-phase systematic review and meta-synthesis
Joshua E.J. Buckman,A. Underwood,Katherine Clarke,Rob Saunders,Steven D. Hollon,Pasco Fearon,Stephen Pilling +6 more
TL;DR: Future research that focuses on understanding causal pathways that link childhood maltreatment to dysfunction in the neocortical and limbic pathways that process affective information and facilitate cognitive control might result in more enduring effects of treatments for depression.
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Interventions for American cutaneous and mucocutaneous leishmaniasis
TL;DR: There is a need for large well conducted studies that evaluate long-term effects of current therapies to improve quality and standardization of methods in therapeutic interventions for American cutaneous and mucocutaneous leishmaniasis.
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Self‐monitoring and self‐management of oral anticoagulation
Carl Heneghan,Josep M. García-Alamino,Elizabeth A Spencer,Alison Ward,Rafael Perera,Clare Bankhead,Pablo Alonso-Coello,David Fitzmaurice,Kamal R Mahtani,Igho Onakpoya +9 more
TL;DR: The quality of evidence was generally low to moderate, and the effects on thrombotic events, major haemorrhages, and all-cause mortality of self-monitoring or self-management of oral anticoagulant therapy compared to standard monitoring was evaluated.
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Environmental interventions to reduce the consumption of sugar‐sweetened beverages and their effects on health
Peter von Philipsborn,Jan M. Stratil,Jacob Burns,Laura K Busert,Lisa M. Pfadenhauer,Stephanie Polus,Christina Holzapfel,Hans Hauner,Eva Rehfuess +8 more
TL;DR: The effects of environmental interventions (excluding taxation) on the consumption of sugar‐sweetened beverages and sugar‐ sweetened milk, diet‐related anthropometric measures and health outcomes, and on any reported unintended consequences or adverse outcomes are assessed.
References
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Journal ArticleDOI
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial
Jacques E. Rossouw,Garnet L. Anderson,Ross L. Prentice,Andrea Z. LaCroix,Charles Kooperberg,Marcia L. Stefanick,Rebecca D. Jackson,Shirley A.A. Beresford,Barbara V. Howard,Karen C. Johnson,Jane Morley Kotchen,Judith K. Ockene +11 more
TL;DR: Overall health risks exceeded benefits from use of combined estrogen plus progestin for an average 5.2-year follow-up among healthy postmenopausal US women, and the results indicate that this regimen should not be initiated or continued for primary prevention of CHD.
Journal ArticleDOI
Randomized Trial of Estrogen Plus Progestin for Secondary Prevention of Coronary Heart Disease in Postmenopausal Women
Stephen B. Hulley,Deborah Grady,Trudy L. Bush,Curt D Furberg,David M. Herrington,Betty Riggs,Eric Vittinghoff +6 more
TL;DR: Treatment with oral conjugated equine estrogen plus medroxyprogesterone acetate did not reduce the overall rate of CHD events in postmenopausal women with established coronary disease and the treatment did increase the rate of thromboembolic events and gallbladder disease.
Journal ArticleDOI
Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial.
Echt Ds,Philip R. Liebson,Mitchell Lb,Robert W. Peters,Obias-Manno D,Barker Ah,Arensberg D,Baker A,Lawrence S. Friedman,Greene Hl +9 more
TL;DR: There was an excess of deathsDue to arrhythmia and deaths due to shock after acute recurrent myocardial infarction in patients treated with encainide or flecainide.
Journal ArticleDOI
A comparison of results of meta-analyses of randomized control trials and recommendations of clinical experts. Treatments for myocardial infarction.
TL;DR: Finding and analyzing all therapeutic trials in a given field has become such a difficult and specialized task that the clinical experts called on to summarize the evidence in a timely fashion need access to better databases and new statistical techniques to assist them.
Journal ArticleDOI
Systems for grading the quality of evidence and the strength of recommendations I: critical appraisal of existing approaches The GRADE Working Group.
David Atkins,Martin P Eccles,Signe Flottorp,Gordon H. Guyatt,David Henry,Suzanne Hill,Alessandro Liberati,Dianne L. O'Connell,Andrew D Oxman,Bob Phillips,Holger J. Schünemann,Holger J. Schünemann,Tessa Tan-Torres Edejer,Gunn Elisabeth Vist,John W Williams +14 more
TL;DR: The objective was to critically appraise six prominent systems for grading levels of evidence and the strength of recommendations as a basis for agreeing on characteristics of a common, sensible approach.