GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Gordon H. Guyatt,Andrew D Oxman,Gunn Elisabeth Vist,Regina Kunz,Yngve Falck-Ytter,Pablo Alonso-Coello,Holger J. Schünemann +6 more
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The advantages of the GRADE system are explored, which is increasingly being adopted by organisations worldwide and which is often praised for its high level of consistency.Abstract:
Guidelines are inconsistent in how they rate the quality of evidence and the strength of recommendations. This article explores the advantages of the GRADE system, which is increasingly being adopted by organisations worldwideread more
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Adverse events associated with nevirapine and efavirenz-based first-line antiretroviral therapy: a systematic review and meta-analysis.
Zara Shubber,Alexandra Calmy,Isabelle Andrieux-Meyer,Marco Vitoria,Françoise Renaud-Théry,Nathan Shaffer,Sally Hargreaves,Edward J Mills,Nathan Ford +8 more
TL;DR: Compared to NVP, EFV is associated with a lower frequency of severe adverse events, in particular treatment discontinuations, which supports a move toward EFV-based therapy as the preferred first-line treatment regimen for HIV treatment within a public health approach.
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Nosocomial infections among patients with COVID-19, SARS and MERS: A rapid review and meta-analysis
Qi Zhou,Yelei Gao,Xingmei Wang,Rui Liu,Peipei Du,Xiaoqing Wang,Xianzhuo Zhang,Shuya Lu,Shuya Lu,Shuya Lu,Zijun Wang,Qianling Shi,Weiguo Li,Yanfang Ma,Xufei Luo,Toshio Fukuoka,Hyeong Sik Ahn,Hyeong Sik Ahn,Myeong Soo Lee,Enmei Liu,Yaolong Chen,Zhengxiu Luo,Kehu Yang,Covid Evidence +23 more
TL;DR: The proportion of nosocomial infection in patients with COVID-19 was 44% in the early outbreak, and nurses and doctors were the most affected among the infected medical staff.
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Don't know, can't know: embracing deeper uncertainties when analysing risks
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TL;DR: The contingent nature of risk-modelling needs to be explicitly acknowledged in advice given to policy-makers, and the forms of expression of uncertainty within the five levels are considered, concluding that unconditional expressions of uncertainty remain an aspiration.
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Palliative Care as a Standard of Care in Pediatric Oncology.
Meaghann S. Weaver,Katherine E. Heinze,Katherine Patterson Kelly,Lori Wiener,Robert L. Casey,Cynthia J. Bell,Joanne Wolfe,Amy Garee,Anne Watson,Pamela S. Hinds +9 more
TL;DR: Standardization of palliative care assessments and interventions in pediatric oncology has the potential to foster improved quality of care across the cancer trajectory for children and adolescents with cancer and their family members.
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Instruments for the assessment of suicide risk: A systematic review evaluating the certainty of the evidence
Bo S. Runeson,Bo S. Runeson,Jenny Odeberg,Agneta Pettersson,Tobias Edbom,Ingalill Jildevik Adamsson,Margda Waern +6 more
TL;DR: Most suicide risk assessment instruments were supported by too few studies to allow for evaluation of accuracy, and among those that could be evaluated, none fulfilled requirements for sufficient diagnostic accuracy.
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David Atkins,Martin P Eccles,Signe Flottorp,Gordon H. Guyatt,David Henry,Suzanne Hill,Alessandro Liberati,Dianne L. O'Connell,Andrew D Oxman,Bob Phillips,Holger J. Schünemann,Holger J. Schünemann,Tessa Tan-Torres Edejer,Gunn Elisabeth Vist,John W Williams +14 more
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