GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Gordon H. Guyatt,Andrew D Oxman,Gunn Elisabeth Vist,Regina Kunz,Yngve Falck-Ytter,Pablo Alonso-Coello,Holger J. Schünemann +6 more
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The advantages of the GRADE system are explored, which is increasingly being adopted by organisations worldwide and which is often praised for its high level of consistency.Abstract:
Guidelines are inconsistent in how they rate the quality of evidence and the strength of recommendations. This article explores the advantages of the GRADE system, which is increasingly being adopted by organisations worldwideread more
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2014 KLCSG-NCC Korea Practice Guideline for the Management of Hepatocellular Carcinoma
TL;DR: This guideline provides recommendations for the initial treatment of patients with newly diagnosed HCC and is developed on the basis of recent evidence and expert opinions.
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Efficacy and safety of treatment with biologicals (benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab) for severe eosinophilic asthma
Ioana Agache,Jessica Beltran,Cezmi A. Akdis,Mübeccel Akdis,Carlos Canelo-Aybar,Giorgio Walter Canonica,Thomas B. Casale,Tomas Chivato,Jonathan Corren,Stefano Del Giacco,Thomas Eiwegger,Davide Firinu,James E. Gern,Eckard Hamelmann,Nicola A. Hanania,Mika J. Mäkelä,Irene Hernández-Martín,Parameswaran Nair,Parameswaran Nair,Liam O'Mahony,Nikolaos G. Papadopoulos,Nikolaos G. Papadopoulos,Alberto Papi,Hae-Sim Park,Luis Pérez de Llano,Margarita Posso,Claudio Rocha,Santiago Quirce,Joaquín Sastre,Mohamed H. Shamji,Mohamed H. Shamji,Yang Song,Corinna Steiner,Jürgen Schwarze,Pablo Alonso-Coello,Oscar Palomares,Marek Jutel +36 more
TL;DR: There is high certainty that all approved biologicals reduce the rate of severe asthma exacerbations and for benralizumab, dupilumab and mepolIZumab for reducing OCS, and there is moderate certainty for improving asthma control, QoL, FEV1.
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Effect of early versus late or no tracheostomy on mortality and pneumonia of critically ill patients receiving mechanical ventilation: a systematic review and meta-analysis
Ilias I. Siempos,Ilias I. Siempos,Ilias I. Siempos,Theodora K. Ntaidou,Filippos T. Filippidis,Augustine M.K. Choi +5 more
TL;DR: The synthesised evidence suggests that early tracheostomy is not associated with lower mortality in the intensive-care unit than late or no trachesostomy, and may be associated with a lower incidence of pneumonia; a finding that could question the present practice of delaying trachostomy beyond the first week after translaryngeal intubation in mechanically ventilated patients.
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Omega 3 fatty acids (fish oil) for maintenance of remission in Crohn's disease
TL;DR: Evidence from two large high quality studies suggests that omega 3 fatty acids are probably ineffective for maintenance of remission in CD, although they may cause diarrhea and upper gastrointestinal tract symptoms.
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Modifications in endoscopic practice for pediatric patients
Jenifer R. Lightdale,Ruben D. Acosta,Amandeep K. Shergill,Vinay Chandrasekhara,Krishnavel V. Chathadi,Dayna S. Early,John A. Evans,Robert D. Fanelli,Deborah A. Fisher,Lisa Fonkalsrud,Joo Ha Hwang,Mouen Kashab,V. Raman Muthusamy,Shabana F. Pasha,John R. Saltzman,Brooks D. Cash +15 more
TL;DR: This paper recommends the use of standard adult duodenoscopes for performing ERCP in children who weigh at least 10 kg and the placement of 12F or 16F percutaneous endoscopic gastrostomy tubes inChildren who weigh less than 50 kg.
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