GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Gordon H. Guyatt,Andrew D Oxman,Gunn Elisabeth Vist,Regina Kunz,Yngve Falck-Ytter,Pablo Alonso-Coello,Holger J. Schünemann +6 more
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The advantages of the GRADE system are explored, which is increasingly being adopted by organisations worldwide and which is often praised for its high level of consistency.Abstract:
Guidelines are inconsistent in how they rate the quality of evidence and the strength of recommendations. This article explores the advantages of the GRADE system, which is increasingly being adopted by organisations worldwideread more
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Effect of CPAP on Blood Pressure in Patients With OSA/Hypopnea: A Systematic Review and Meta-analysis
Cristiano Fava,Stefania Dorigoni,Francesco Dalle Vedove,Elisa Danese,Martina Montagnana,Gian Cesare Guidi,Krzysztof Narkiewicz,Pietro Minuz +7 more
TL;DR: Therapy with CPAP significantly reduces BP in patients with OSA but with a low effect size, and patients with frequent apneic episodes may benefit the most from CPAP.
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The 2020 Canadian Cardiovascular Society/Canadian Heart Rhythm Society Comprehensive Guidelines for the Management of Atrial Fibrillation
Jason G. Andrade,Jason G. Andrade,Martin Aguilar,Clare L. Atzema,Alan Bell,John A. Cairns,Christopher C. Cheung,Jafna L. Cox,Paul Dorian,David J. Gladstone,Jeff S. Healey,Paul Khairy,Kori Leblanc,M. Sean McMurtry,L. Brent Mitchell,Girish M. Nair,Stanley Nattel,Ratika Parkash,Louise Pilote,Roopinder K. Sandhu,Jean-François Sarrazin,Mukul Sharma,Allan C. Skanes,Mario Talajic,Teresa S.M. Tsang,Atul Verma,Subodh Verma,Richard P. Whitlock,D. George Wyse,Laurent Macle +29 more
TL;DR: The 2020 iteration of the CCS AF guidelines represents a comprehensive renewal that integrates, updates, and replaces the past decade of guidelines, recommendations, and practical tips.
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Interventions for primary vesicoureteric reflux
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Benefits and Harms of Statin Therapy for Persons With Chronic Kidney Disease
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TL;DR: In this paper, a review of 89 trials summarizes evidence on the benefits and harms of statin therapy for adults with chronic kidney disease (CKD) with varying severity of CKD.
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Interferon-γ Release Assays for Active Pulmonary Tuberculosis Diagnosis in Adults in Low- and Middle-Income Countries: Systematic Review and Meta-analysis
John Z. Metcalfe,Charles K. Everett,Karen R Steingart,Adithya Cattamanchi,Adithya Cattamanchi,Laurence Huang,Philip C. Hopewell,Philip C. Hopewell,Madhukar Pai +8 more
TL;DR: In low- and middle-income countries, neither the tuberculin skin test nor IGRAs have value for active tuberculosis diagnosis in adults, especially in the context of HIV coinfection.
References
More filters
Journal ArticleDOI
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial
Jacques E. Rossouw,Garnet L. Anderson,Ross L. Prentice,Andrea Z. LaCroix,Charles Kooperberg,Marcia L. Stefanick,Rebecca D. Jackson,Shirley A.A. Beresford,Barbara V. Howard,Karen C. Johnson,Jane Morley Kotchen,Judith K. Ockene +11 more
TL;DR: Overall health risks exceeded benefits from use of combined estrogen plus progestin for an average 5.2-year follow-up among healthy postmenopausal US women, and the results indicate that this regimen should not be initiated or continued for primary prevention of CHD.
Journal ArticleDOI
Randomized Trial of Estrogen Plus Progestin for Secondary Prevention of Coronary Heart Disease in Postmenopausal Women
Stephen B. Hulley,Deborah Grady,Trudy L. Bush,Curt D Furberg,David M. Herrington,Betty Riggs,Eric Vittinghoff +6 more
TL;DR: Treatment with oral conjugated equine estrogen plus medroxyprogesterone acetate did not reduce the overall rate of CHD events in postmenopausal women with established coronary disease and the treatment did increase the rate of thromboembolic events and gallbladder disease.
Journal ArticleDOI
Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial.
Echt Ds,Philip R. Liebson,Mitchell Lb,Robert W. Peters,Obias-Manno D,Barker Ah,Arensberg D,Baker A,Lawrence S. Friedman,Greene Hl +9 more
TL;DR: There was an excess of deathsDue to arrhythmia and deaths due to shock after acute recurrent myocardial infarction in patients treated with encainide or flecainide.
Journal ArticleDOI
A comparison of results of meta-analyses of randomized control trials and recommendations of clinical experts. Treatments for myocardial infarction.
TL;DR: Finding and analyzing all therapeutic trials in a given field has become such a difficult and specialized task that the clinical experts called on to summarize the evidence in a timely fashion need access to better databases and new statistical techniques to assist them.
Journal ArticleDOI
Systems for grading the quality of evidence and the strength of recommendations I: critical appraisal of existing approaches The GRADE Working Group.
David Atkins,Martin P Eccles,Signe Flottorp,Gordon H. Guyatt,David Henry,Suzanne Hill,Alessandro Liberati,Dianne L. O'Connell,Andrew D Oxman,Bob Phillips,Holger J. Schünemann,Holger J. Schünemann,Tessa Tan-Torres Edejer,Gunn Elisabeth Vist,John W Williams +14 more
TL;DR: The objective was to critically appraise six prominent systems for grading levels of evidence and the strength of recommendations as a basis for agreeing on characteristics of a common, sensible approach.