GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Gordon H. Guyatt,Andrew D Oxman,Gunn Elisabeth Vist,Regina Kunz,Yngve Falck-Ytter,Pablo Alonso-Coello,Holger J. Schünemann +6 more
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The advantages of the GRADE system are explored, which is increasingly being adopted by organisations worldwide and which is often praised for its high level of consistency.Abstract:
Guidelines are inconsistent in how they rate the quality of evidence and the strength of recommendations. This article explores the advantages of the GRADE system, which is increasingly being adopted by organisations worldwideread more
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International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer
Dominique Farge,Philippe Debourdeau,M Beckers,C. Baglin,Rupert Bauersachs,Barry M. Brenner,Dialina Brilhante,Anna Falanga,G T Gerotzafias,Nissim Haim,Ajay K. Kakkar,Alok A. Khorana,Ramón Lecumberri,Mario Mandalà,Michel Marty,Manuel Monreal,Shaker A. Mousa,Simon Noble,Ingrid Pabinger,Paolo Prandoni,Martin H. Prins,Mohammed H. Qari,Michael B. Streiff,Konstantinos N. Syrigos,Henri Bounameaux,H. R. Büller +25 more
TL;DR: The use of LMWH for VTE prevention in cancer patients undergoing laparoscopic surgery may be recommended as for laparotomy and mechanical methods are not recommended as monotherapy except when pharmacological methods are contraindicated.
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European Stroke Organisation (ESO) guidelines for the management of spontaneous intracerebral hemorrhage
Thorsten Steiner,Rustam Al-Shahi Salman,Ronnie Beer,Hanne Christensen,Charlotte Cordonnier,László Csiba,Michael Forsting,Sagi Harnof,Catharina J.M. Klijn,Derk W. Krieger,A. David Mendelow,Carlos A. Molina,Joan Montaner,Karsten Overgaard,Jesper Petersson,Risto O. Roine,Erich Schmutzhard,Karsten Schwerdtfeger,Christian Stapf,Turgut Tatlisumak,Brenda Thomas,Danilo Toni,Andreas Unterberg,Markus Wagner +23 more
TL;DR: Moderate- to high-quality evidence is found to support weak recommendations for intensive lowering of systolic blood pressure to <140 mmHg within six-hours of ICH onset, early surgery for patients with a Glasgow Coma Scale score 9–12, and avoidance of corticosteroids.
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Management of ingested foreign bodies and food impactions
Steven O. Ikenberry,Terry L. Jue,Michelle A. Anderson,Vasundhara Appalaneni,Subhas Banerjee,Tamir Ben-Menachem,G. Anton Decker,Robert D. Fanelli,Laurel Fisher,Norio Fukami,M. Edwyn Harrison,Rajeev Jain,Khalid Khan,Mary L. Krinsky,John T. Maple,Ravi Sharaf,Laura Strohmeyer,Jason A. Dominitz +17 more
TL;DR: This guideline is intended to be an educational device to provide information that may assist endoscopists in providing care to patients and is not a rule and should not be construed as establishing a legal standard of care.
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ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries
TL;DR: The evaluation of hepatocellular injury includes testing for viral hepatitis A, B, and C, assessment for nonalcoholic fatty liver disease and alcoholic liver disease, screening for hereditary hemochromatosis, autoimmune hepatitis, Wilson’s disease, and alpha-1 antitrypsin deficiency.
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Interventions for improving upper limb function after stroke
Alex Pollock,Sybil E. Farmer,Marian C. Brady,Peter Langhorne,Gillian Mead,Jan Mehrholz,Frederike van Wijck +6 more
TL;DR: A Cochrane overview of systematic reviews of interventions provided to improve upper limb function after stroke found moderate-quality evidence showed a beneficial effect of constraint-induced movement therapy, mental practice, mirror therapy, interventions for sensory impairment, virtual reality and a relatively high dose of repetitive task practice, suggesting that these may be effective interventions.
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David Atkins,Martin P Eccles,Signe Flottorp,Gordon H. Guyatt,David Henry,Suzanne Hill,Alessandro Liberati,Dianne L. O'Connell,Andrew D Oxman,Bob Phillips,Holger J. Schünemann,Holger J. Schünemann,Tessa Tan-Torres Edejer,Gunn Elisabeth Vist,John W Williams +14 more
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