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GRADE: an emerging consensus on rating quality of evidence and strength of recommendations

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TLDR
The advantages of the GRADE system are explored, which is increasingly being adopted by organisations worldwide and which is often praised for its high level of consistency.
Abstract
Guidelines are inconsistent in how they rate the quality of evidence and the strength of recommendations. This article explores the advantages of the GRADE system, which is increasingly being adopted by organisations worldwide

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Psychological interventions for ICD-11 complex PTSD symptoms: systematic review and meta-analysis

TL;DR: The development of effective interventions for CPTSD can build upon the success of PTSD interventions, and the benefits of flexibility in intervention selection, sequencing and delivery should be assessed, based on clinical need and patient preferences.
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Active body surface warming systems for preventing complications caused by inadvertent perioperative hypothermia in adults

TL;DR: Assessment of the effectiveness of pre- or intraoperative active body surface warming systems (ABSW) to prevent perioperative complications from unintended hypothermia during surgery in adults found no beneficial effect for mortality.
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Anaesthetic care of patients undergoing primary hip and knee arthroplasty: consensus recommendations from the International Consensus on Anaesthesia-Related Outcomes after Surgery group (ICAROS) based on a systematic review and meta-analysis.

TL;DR: Recommendation: primary neuraxial anaesthesia is preferred for knee arthroplasty, given several positive postoperative outcome benefits; evidence level: low, weak recommendation.
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Enriched Environments and Motor Outcomes in Cerebral Palsy: Systematic Review and Meta-analysis

TL;DR: High-quality studies with well-defined EE strategies are urgently required for improving the motor outcomes of infants at high risk of cerebral palsy, and therefore EE looks promising for CP.
References
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Journal ArticleDOI

Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial

TL;DR: Overall health risks exceeded benefits from use of combined estrogen plus progestin for an average 5.2-year follow-up among healthy postmenopausal US women, and the results indicate that this regimen should not be initiated or continued for primary prevention of CHD.
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Randomized Trial of Estrogen Plus Progestin for Secondary Prevention of Coronary Heart Disease in Postmenopausal Women

TL;DR: Treatment with oral conjugated equine estrogen plus medroxyprogesterone acetate did not reduce the overall rate of CHD events in postmenopausal women with established coronary disease and the treatment did increase the rate of thromboembolic events and gallbladder disease.
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Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial.

TL;DR: There was an excess of deathsDue to arrhythmia and deaths due to shock after acute recurrent myocardial infarction in patients treated with encainide or flecainide.
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A comparison of results of meta-analyses of randomized control trials and recommendations of clinical experts. Treatments for myocardial infarction.

TL;DR: Finding and analyzing all therapeutic trials in a given field has become such a difficult and specialized task that the clinical experts called on to summarize the evidence in a timely fashion need access to better databases and new statistical techniques to assist them.
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