GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Gordon H. Guyatt,Andrew D Oxman,Gunn Elisabeth Vist,Regina Kunz,Yngve Falck-Ytter,Pablo Alonso-Coello,Holger J. Schünemann +6 more
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The advantages of the GRADE system are explored, which is increasingly being adopted by organisations worldwide and which is often praised for its high level of consistency.Abstract:
Guidelines are inconsistent in how they rate the quality of evidence and the strength of recommendations. This article explores the advantages of the GRADE system, which is increasingly being adopted by organisations worldwideread more
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Efficacy and safety of corticosteroids in COVID-19 based on evidence for COVID-19, other coronavirus infections, influenza, community-acquired pneumonia and acute respiratory distress syndrome: a systematic review and meta-analysis.
Zhikang Ye,Ying Wang,Luis Enrique Colunga-Lozano,Manya Prasad,Wimonchat Tangamornsuksan,Bram Rochwerg,Liang Yao,Shahrzad Motaghi,Rachel Couban,Maryam Ghadimi,Malgorzata M. Bala,Huda Gomaa,Fang Fang,Yingqi Xiao,Gordon H. Guyatt +14 more
TL;DR: Corticosteroids may reduce mortality for patients with COVID-19 and ARDS and Randomized controlled trials in CAP suggest that corticosteroid may reduce deaths, and may increase hyperglycemia.
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Effectiveness of Stretch for the Treatment and Prevention of Contractures in People With Neurological Conditions: A Systematic Review
TL;DR: Regular stretch does not produce clinically important changes in joint mobility, pain, spasticity, or activity limitation in people with neurological conditions.
Journal ArticleDOI
Management of giant cell arteritis: Recommendations of the French Study Group for Large Vessel Vasculitis (GEFA).
Boris Bienvenu,K.H. Ly,Marc Lambert,Christian Agard,Marc André,Ygal Benhamou,Bernard Bonnotte,H. De Boysson,Olivier Espitia,G. Fau,Anne-Laure Fauchais,Françoise Galateau-Salle,Julien Haroche,E. Héron,F.X. Lapébie,Eric Liozon,L.B. Luong Nguyen,J. Magnant,Alain Manrique,M. Matt,M. de Menthon,Luc Mouthon,Xavier Puéchal,Grégory Pugnet,Thomas Quemeneur,Alexis Régent,David Saadoun,Maxime Samson,Damien Sène,P. Smets,Cécile Yelnik,Laurent Sailler,Alfred Mahr +32 more
TL;DR: The recommendations, which will be updated regularly, are intended to guide and harmonize the standards of GCA management.
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Intermittent fasting interventions for treatment of overweight and obesity in adults: a systematic review and meta-analysis.
Leanne Harris,Sharon Hamilton,Sharon Hamilton,Liane B. Azevedo,Liane B. Azevedo,Joan Olajide,Joan Olajide,Caroline De Brun,Caroline De Brun,Gillian Waller,Gillian Waller,Vicki Whittaker,Vicki Whittaker,Tracey Sharp,Michael E. J. Lean,Catherine Hankey,Louisa Ells,Louisa Ells +17 more
TL;DR: Intermittent energy restriction was comparable to continuous energy restriction for short term weight loss in overweight and obese adults, however, this should be interpreted cautiously due to the small number of studies and future research is warranted to confirm the findings.
Journal ArticleDOI
Aminosalicylates for induction of remission or response in Crohn's disease
TL;DR: A non-significant trend in favour of sulfasalazine over placebo for inducing remission was observed, with benefit confined mainly to patients with Crohn's colitis, while the overall quality of the evidence supporting this outcome was moderate due to sparse data.
References
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David Atkins,Martin P Eccles,Signe Flottorp,Gordon H. Guyatt,David Henry,Suzanne Hill,Alessandro Liberati,Dianne L. O'Connell,Andrew D Oxman,Bob Phillips,Holger J. Schünemann,Holger J. Schünemann,Tessa Tan-Torres Edejer,Gunn Elisabeth Vist,John W Williams +14 more
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