GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Gordon H. Guyatt,Andrew D Oxman,Gunn Elisabeth Vist,Regina Kunz,Yngve Falck-Ytter,Pablo Alonso-Coello,Holger J. Schünemann +6 more
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The advantages of the GRADE system are explored, which is increasingly being adopted by organisations worldwide and which is often praised for its high level of consistency.Abstract:
Guidelines are inconsistent in how they rate the quality of evidence and the strength of recommendations. This article explores the advantages of the GRADE system, which is increasingly being adopted by organisations worldwideread more
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Oral immunotherapy for IgE‐mediated cow's milk allergy: a systematic review and meta‐analysis
Jan Brozek,Luigi Terracciano,Jonathan C. Hsu,J. Kreis,J. Kreis,Enrico Compalati,Nancy Santesso,Alessandro Fiocchi,Holger J. Schünemann +8 more
TL;DR: A systematic review of randomized controlled trials and observational studies to assess the evidence supporting the use of oral immunotherapy in IgE‐mediated cow's milk allergy to inform the World Allergy Organization guidelines concluded that additional, larger RCTs measuring all patient‐important outcomes are still needed.
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NASPGHAN Practice Guidelines: Diagnosis and Management of Hepatitis C Infection in Infants, Children, and Adolescents
Cara L. Mack,Regino P. Gonzalez-Peralta,Nitika A. Gupta,Daniel Leung,Michael R. Narkewicz,Eve A. Roberts,Philip J. Rosenthal,Kathleen B. Schwarz +7 more
TL;DR: The guideline details the epidemiology and natural history of HCV infection in children, the diagnostic workup, monitoring and treatment of disease, and provides an update on future treatment options and areas of research.
Journal ArticleDOI
Healthy food subsidies and unhealthy food taxation: A systematic review of the evidence
TL;DR: Although moderate in quality, there was consistent evidence that taxation and subsidy intervention influenced dietary behaviors, and the quality, level and strength of evidence along with identified gaps in research support the need for further policies and ongoing evaluation of population-wide food/beverage subsidies and taxation.
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Meta-analysis of antibiotics versus appendicectomy for non-perforated acute appendicitis
Ville Sallinen,Elie A. Akl,Elie A. Akl,John J. You,Arnav Agarwal,Arnav Agarwal,Sami Shoucair,Per Olav Vandvik,Thomas Agoritsas,Diane Heels-Ansdell,Gordon H. Guyatt,Kari A.O. Tikkinen +11 more
TL;DR: This study assessed the benefits and harms of antibiotic therapy compared with appendicectomy in patients with non‐perforated appendicitis.
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The role of endoscopy in the management of choledocholithiasis
John T. Maple,Laurel Fisher,Norio Fukami,Joo Ha Hwang,Rajeev Jain,Terry L. Jue,Khalid Khan,Mary L. Krinsky,Phyllis M. Malpas,Tamir Ben-Menachem,Ravi Sharaf,Jason A. Dominitz,Steven O. Ikenberry,Michelle A. Anderson,Vasundhara Appalaneni,G. Anton Decker,Dayna S. Early,John A. Evans,Robert D. Fanelli,Deborah A. Fisher +19 more
TL;DR: This guideline is intended to be an educational device o provide information that may assist endoscopists in roviding care to patients that is based on both the aggregate evidence quality and an assessment of the anticipated benefits and harms.
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