GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Gordon H. Guyatt,Andrew D Oxman,Gunn Elisabeth Vist,Regina Kunz,Yngve Falck-Ytter,Pablo Alonso-Coello,Holger J. Schünemann +6 more
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The advantages of the GRADE system are explored, which is increasingly being adopted by organisations worldwide and which is often praised for its high level of consistency.Abstract:
Guidelines are inconsistent in how they rate the quality of evidence and the strength of recommendations. This article explores the advantages of the GRADE system, which is increasingly being adopted by organisations worldwideread more
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The difficult airway with recommendations for management - Part 1 - Difficult tracheal intubation encountered in an unconscious/induced patient Prise en charge des voies aeriennes - 1re partie - Recommandations lorsque des difficultes sont constatees chez le patient inconscient/anesthesie ´
J. Adam Law,Matthew L. Cooper,Laura V. Duggan,E. Griesdale,R. Hung,Philip M. Jones,R. Morris,Timothy Mullen,F. Murphy,N. Naik,Jeanette Scott,P. Turkstra,Tony Wong +12 more
TL;DR: The Canadian Airway Focus Group (CAFG) as discussed by the authors made recommendations on management of difficult tracheal intubation in a 1998 publication and has since reconvened to examine more recent scientific literature on airway management.
Journal ArticleDOI
Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child
Jennifer Weston,Rebecca Bromley,Cerian F Jackson,Naghme Adab,Jill Clayton-Smith,Janette Greenhalgh,Juliet Hounsome,Andrew McKay,Catrin Tudur Smith,Anthony G Marson +9 more
TL;DR: The effects of prenatal exposure to AEDs on the prevalence of congenital malformations in the child were assessed and biases were balanced across the Aeds investigated and the results are not explained by these biases.
Journal ArticleDOI
A rapid evidence review of the effectiveness and cost-effectiveness of alcohol control policies: an English perspective
Robyn Burton,Robyn Burton,Clive Henn,Don Lavoie,Rosanna O'Connor,Clare Perkins,Kate Sweeney,Felix Greaves,Felix Greaves,Brian Ferguson,Brian Ferguson,Caryl Beynon,Annalisa Belloni,Virginia Musto,John Marsden,John Marsden,Nick Sheron,Nick Sheron +17 more
TL;DR: There is a rich evidence base to support the decisions of policy makers in implementing the most effective and cost-effective policies to reduce alcohol-related harm.
Journal ArticleDOI
Using alternative statistical formats for presenting risks and risk reductions
Elie A. Akl,Andrew D Oxman,Jeph Herrin,Gunn Elisabeth Vist,Irene Terrenato,Francesca Sperati,Cecilia T. Costiniuk,Diana Blank,Holger J. Schünemann +8 more
TL;DR: Relative risk reduction (RRR), compared with absolute risk Reduction (ARR) and number needed to treat (NNT), may be perceived to be larger and is more likely to be persuasive, but it is uncertain whether presenting RRR is likely to help people make decisions most consistent with their own values and, in fact, it could lead to misinterpretation.
Journal ArticleDOI
Use of probiotics for management of acute gastroenteritis: a position paper by the ESPGHAN Working Group for Probiotics and Prebiotics.
Hania Szajewska,Alfredo Guarino,Iva Hojsak,Flavia Indrio,Sanja Kolaček,Raanan Shamir,Yvan Vandenplas,Zvi Weizman +7 more
TL;DR: This document provides recommendations for the use of probiotics for the treatment of AGE in previously healthy infants and children based on a systematic review of previously completed systematic reviews and of randomized controlled trials (RCTs) published subsequently to these reviews.
References
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Journal ArticleDOI
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial
Jacques E. Rossouw,Garnet L. Anderson,Ross L. Prentice,Andrea Z. LaCroix,Charles Kooperberg,Marcia L. Stefanick,Rebecca D. Jackson,Shirley A.A. Beresford,Barbara V. Howard,Karen C. Johnson,Jane Morley Kotchen,Judith K. Ockene +11 more
TL;DR: Overall health risks exceeded benefits from use of combined estrogen plus progestin for an average 5.2-year follow-up among healthy postmenopausal US women, and the results indicate that this regimen should not be initiated or continued for primary prevention of CHD.
Journal ArticleDOI
Randomized Trial of Estrogen Plus Progestin for Secondary Prevention of Coronary Heart Disease in Postmenopausal Women
Stephen B. Hulley,Deborah Grady,Trudy L. Bush,Curt D Furberg,David M. Herrington,Betty Riggs,Eric Vittinghoff +6 more
TL;DR: Treatment with oral conjugated equine estrogen plus medroxyprogesterone acetate did not reduce the overall rate of CHD events in postmenopausal women with established coronary disease and the treatment did increase the rate of thromboembolic events and gallbladder disease.
Journal ArticleDOI
Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial.
Echt Ds,Philip R. Liebson,Mitchell Lb,Robert W. Peters,Obias-Manno D,Barker Ah,Arensberg D,Baker A,Lawrence S. Friedman,Greene Hl +9 more
TL;DR: There was an excess of deathsDue to arrhythmia and deaths due to shock after acute recurrent myocardial infarction in patients treated with encainide or flecainide.
Journal ArticleDOI
A comparison of results of meta-analyses of randomized control trials and recommendations of clinical experts. Treatments for myocardial infarction.
TL;DR: Finding and analyzing all therapeutic trials in a given field has become such a difficult and specialized task that the clinical experts called on to summarize the evidence in a timely fashion need access to better databases and new statistical techniques to assist them.
Journal ArticleDOI
Systems for grading the quality of evidence and the strength of recommendations I: critical appraisal of existing approaches The GRADE Working Group.
David Atkins,Martin P Eccles,Signe Flottorp,Gordon H. Guyatt,David Henry,Suzanne Hill,Alessandro Liberati,Dianne L. O'Connell,Andrew D Oxman,Bob Phillips,Holger J. Schünemann,Holger J. Schünemann,Tessa Tan-Torres Edejer,Gunn Elisabeth Vist,John W Williams +14 more
TL;DR: The objective was to critically appraise six prominent systems for grading levels of evidence and the strength of recommendations as a basis for agreeing on characteristics of a common, sensible approach.