GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Gordon H. Guyatt,Andrew D Oxman,Gunn Elisabeth Vist,Regina Kunz,Yngve Falck-Ytter,Pablo Alonso-Coello,Holger J. Schünemann +6 more
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The advantages of the GRADE system are explored, which is increasingly being adopted by organisations worldwide and which is often praised for its high level of consistency.Abstract:
Guidelines are inconsistent in how they rate the quality of evidence and the strength of recommendations. This article explores the advantages of the GRADE system, which is increasingly being adopted by organisations worldwideread more
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Reducing intrapartum-related deaths and disability: Can the health system deliver?
Joy E Lawn,Mary V Kinney,Anne C C Lee,Mickey Chopra,Vinod K. Paul,Zulfiqar A Bhutta,Massee Bateman,Gary L. Darmstadt,Gary L. Darmstadt +8 more
TL;DR: In this paper, the authors summarized the results of a systematic evidence review, and synthesize actions required to strengthen healthcare delivery systems and home care to reduce intrapartum-related deaths.
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Effect of Influenza Vaccination of Healthcare Personnel on Morbidity and Mortality Among Patients: Systematic Review and Grading of Evidence
TL;DR: The quality of evidence for the effect of HCP vaccination on mortality and influenza cases in patients was moderate and low, respectively, and the overall evidence quality was moderate.
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The clinical aspects of mirror therapy in rehabilitation: a systematic review of the literature.
TL;DR: There is a moderate quality ofEvidence that MT as an additional intervention improves recovery of arm function, and a low quality of evidence regarding lower limb function and pain after stroke, and the quality ofevidence in patients with complex regional pain syndrome and phantom limb pain is low.
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Trastuzumab-containing regimens for metastatic breast cancer.
Sara Balduzzi,Stefania Mantarro,Valentina Guarneri,Ludovica Tagliabue,Vanna Pistotti,Lorenzo Moja,Roberto D'Amico +6 more
TL;DR: The evidence on the efficacy and safety of therapy with trastuzumab (overall) and in relation to the type of co-administered regimen and the line of treatment, i.e. first-line or beyond progression, in women with HER2-positive metastatic breast cancer was assessed.
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David Atkins,Martin P Eccles,Signe Flottorp,Gordon H. Guyatt,David Henry,Suzanne Hill,Alessandro Liberati,Dianne L. O'Connell,Andrew D Oxman,Bob Phillips,Holger J. Schünemann,Holger J. Schünemann,Tessa Tan-Torres Edejer,Gunn Elisabeth Vist,John W Williams +14 more
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