Interchromosomal association and gene regulation in trans.
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TLDR
Evidence is emerging that regulatory elements might have the capacity to act in trans to regulate genes on other chromosomes, but unequivocal data required to prove that interchromosomal gene regulation truly represents another level of control within the nucleus is lacking and this concept remains highly contentious.About:
This article is published in Trends in Genetics.The article was published on 2010-04-01 and is currently open access. It has received 98 citations till now. The article focuses on the topics: Regulation of gene expression.read more
Citations
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Journal ArticleDOI
The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome
Jesse M. Engreitz,Amy Pandya-Jones,Patrick McDonel,Alexander A. Shishkin,Klara Sirokman,Christine Surka,Sabah Kadri,Jeffrey C. Xing,Alon Goren,Eric S. Lander,Eric S. Lander,Eric S. Lander,Kathrin Plath,Mitchell Guttman +13 more
TL;DR: In this article, the authors investigated the localization mechanisms of the Xist lncRNA during X-chromosome inactivation (XCI), a paradigm of lncRN-mediated chromatin regulation.
The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome
Jesse M. Engreitz,Amy Pandya-Jones,Patrick McDonel,Alexander A. Shishkin,Klara Sirokman,Christine Surka,Sabah Kadri,Jeffrey C. Xing,Alon Goren,Eric S. Lander,Eric S. Lander,Eric S. Lander,Kathrin Plath,Mitchell Guttman +13 more
TL;DR: The data suggest a model for how Xist can integrate its two functions—localization to DNA and silencing of gene expression—to coat the entire X chromosome.
Long-Range Directional Movement of an Interphase Chromosome Site Dependent on Actin and Nuclear Myosin
TL;DR: The results suggest an active mechanism for fast and directed long-range interphase chromosome movements dependent directly or indirectly on actin/myosin.
Journal ArticleDOI
Topology of mammalian developmental enhancers and their regulatory landscapes
TL;DR: Recent research shows that high-order chromosome structures make an important contribution to enhancer functionality by triggering their physical interactions with target genes.
Journal ArticleDOI
Polycomb-dependent regulatory contacts between distant Hox loci in Drosophila
Frédéric Bantignies,Virginie Roure,Itys Comet,Benjamin Leblanc,Bernd Schuettengruber,Jerome Bonnet,Vanessa Tixier,André Mas,Giacomo Cavalli +8 more
TL;DR: It is shown that genes of the two Hox complexes can interact within nuclear PcG bodies in tissues where they are corepressed, resulting in the exacerbation of homeotic phenotypes in sensitized genetic backgrounds.
References
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Erez Lieberman Aiden,Nynke L. van Berkum,Louise Williams,Maxim Imakaev,Tobias Ragoczy,Tobias Ragoczy,Agnes Telling,Agnes Telling,Ido Amit,Bryan R. Lajoie,Peter J. Sabo,Michael O. Dorschner,Richard Sandstrom,Bradley E. Bernstein,Bradley E. Bernstein,Michaël Bender,Mark Groudine,Mark Groudine,Andreas Gnirke,John A. Stamatoyannopoulos,Leonid A. Mirny,Eric S. Lander,Eric S. Lander,Job Dekker +23 more
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Capturing Chromosome Conformation
TL;DR: Using the yeast Saccharomyces cerevisiae, this work could confirm known qualitative features of chromosome organization within the nucleus and dynamic changes in that organization during meiosis and found that chromatin is highly flexible throughout.
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Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells
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TL;DR: This study uses chromatin immunoprecipitation coupled with ultra-high-throughput DNA sequencing to map the locations of TF-binding sites and identifies important features of the transcriptional regulatory networks that define ES-cell identity.
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CTCF: Master Weaver of the Genome
TL;DR: It is suggested that CTCF may be a heritable component of an epigenetic system regulating the interplay between DNA methylation, higher-order chromatin structure, and lineage-specific gene expression.
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