Journal ArticleDOI
Life and Death of Neurons in the Aging Brain
John H. Morrison,Patrick R. Hof +1 more
TLDR
The qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored.Abstract:
Neurodegenerative disorders are characterized by extensive neuron death that leads to functional decline, but the neurobiological correlates of functional decline in normal aging are less well defined. For decades, it has been a commonly held notion that widespread neuron death in the neocortex and hippocampus is an inevitable concomitant of brain aging, but recent quantitative studies suggest that neuron death is restricted in normal aging and unlikely to account for age-related impairment of neocortical and hippocampal functions. In this article, the qualitative and quantitative differences between aging and Alzheimer's disease with respect to neuron loss are discussed, and age-related changes in functional and biochemical attributes of hippocampal circuits that might mediate functional decline in the absence of neuron death are explored. When these data are viewed comprehensively, it appears that the primary neurobiological substrates for functional impairment in aging differ in important ways from those in neurodegenerative disorders such as Alzheimer's disease.read more
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Book ChapterDOI
Glucocorticoids and the aging brain; cause or consequence?
Paul J. Lucassen,E.R. de Kloet +1 more
TL;DR: If changes in corticosteroid levels are the cause or consequence of the aging process and age-related brain pathology, accumulating evidence suggests that corticosterone levels are not consistently elevated in aging, however, if cortic Fosteroid levels circulate in aberrant concentrations, they do increase the vulnerability to cognitive decline and disease, rather than aging per se.
Journal ArticleDOI
Sex effects of interleukin-6 deficiency on neuroinflammation in aged C57Bl/6 mice.
V.M. Miller,David A. Lawrence,David A. Lawrence,G.A. Coccaro,Tapan K. Mondal,K. Andrews,A. Dreiem,A. Dreiem,R.F. Seegal,R.F. Seegal +9 more
TL;DR: It is suggested that IL- 6 is important for promoting myelin synthesis in aged females, and that drugs which inhibit the synthesis of IL-6 in males may inadvertently affect fatty acid metabolism and augment aging-related neuroinflammation.
Journal ArticleDOI
Region-specific reduction of Gβ4 expression and induction of the phosphorylation of PKB/Akt and ERK1/2 by aging in rat brain
TL;DR: Current data represent the first demonstration of a change in G beta(4) expression with age in rat brain and suggest that an age-related alteration in expression level of Gbeta( 4) may, at least in part, play an important role in aging processes.
Journal ArticleDOI
Envejecimiento: Cambios bioquímicos y funcionales del Sistema Nervioso Central
M Bernhardi,Rommy von +1 more
TL;DR: In this paper, a trabajo se discutira algunos of los mecanismos neurobiologicos que podrian estar envueltos en el envejecimiento del sistema nervioso.
Journal ArticleDOI
Role of Nutrition to Promote Healthy Brain Aging and Reduce Risk of Alzheimer’s Disease
Michelle Walters,Katherine Hackett,Emily Caesar,Richard S. Isaacson,Lisa Mosconi,Lisa Mosconi +5 more
TL;DR: Proposed nutritional interventions for AD prevention that focus on adopting dietary patterns and improvement of macro- and micronutrient distribution or intakes, improvement of insulin resistance, correction of dyslipidemia, and reduction of oxidative stress are reviewed.
References
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